NVIDIA (NVDA) had the highest return between 2014 and 2016 by a large-cap US stock, returning 600.5%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2014-2016	600.48%
Neurocrine Biosciences (NBIX)	2014-2016	317.48%
Genmab A-S (GMAB)	2014-2016	313.33%
Broadcom (AVGO)	2014-2016	249.09%
Electronic Arts (EA)	2014-2016	243.93%
Texas Pacific Land Trust (TPL)	2014-2016	200.2%
Centrais Electricas Brasileiras (EBR)	2014-2016	198.93%
Advanced Micro Devices (AMD)	2014-2016	194.55%
NetEase (NTES)	2014-2016	191.83%
Take-Two Interactive Software (TTWO)	2014-2016	185.41%
Edwards Lifesciences (EW)	2014-2016	185.32%
Skyworks Solutions (SWKS)	2014-2016	172.54%
Southwest Airlines (LUV)	2014-2016	170.62%
MACOM Technology Solutions (MTSI)	2014-2016	168.29%
Ulta Beauty (ULTA)	2014-2016	164.98%
Burlington Stores (BURL)	2014-2016	164.84%
Grupo Financiero Galicia SA ADR (GGAL)	2014-2016	158.22%
Paycom Soft (PAYC)	2014-2016	154.13%
Coca-Cola Consolidated (COKE)	2014-2016	151.83%
Monolithic Power Systems (MPWR)	2014-2016	146.26%
Netflix (NFLX)	2014-2016	136.25%
Martin Marietta Materials (MLM)	2014-2016	129.83%
CDW (CDW)	2014-2016	128.68%
Frank's International (FI)	2014-2016	125.26%
UnitedHealth (UNH)	2014-2016	124.54%

Large-cap stocks are treated as having a market cap of $10B+.