Applovin (APP) has had the highest return between 2024 and 2025 by a large-cap US stock, returning 864.9%.

ASSET	YEARS	% RETURN
Applovin (APP)	2024-2025	864.88%
Summit Therapeutics (SMMT)	2024-2025	699.22%
Reddit (RDDT)	2024-2025	533.26%
Palantir Technologies Inc Class A Common Stock (PLTR)	2024-2025	512.57%
Rocket Lab USA (RKLB)	2024-2025	426.24%
MicroStrategy (MSTR)	2024-2025	402.98%
Carvana (CVNA)	2024-2025	399.22%
Celestica (CLS)	2024-2025	360.82%
Vistra Energy (VST)	2024-2025	344.05%
Robinhood Markets (HOOD)	2024-2025	312.72%
Grupo Financiero Galicia SA ADR (GGAL)	2024-2025	311.14%
Credo Technology (CRDO)	2024-2025	300.68%
Sprouts Farmers Market LLC (SFM)	2024-2025	245.81%
CAVA (CAVA)	2024-2025	235.31%
Spotify Technology (SPOT)	2024-2025	230.64%
GE Vernova LLC (GEV)	2024-2025	210.26%
Ubiquiti Networks (UI)	2024-2025	208.48%
Flex (FLEX)	2024-2025	207.97%
Sea (SE)	2024-2025	207.88%
Natera (NTRA)	2024-2025	182.49%
Interactive Brokers (IBKR)	2024-2025	168.04%
Constellation Energy (CEG)	2024-2025	165%
United Airlines (UAL)	2024-2025	164.21%
Insmed (INSM)	2024-2025	163.02%
Texas Pacific Land Trust (TPL)	2024-2025	162.08%

Large-cap stocks are treated as having a market cap of $10B+.