YPF Sociedad Anonima (YPF) has had the highest return between 2022 and 2025 by a large-cap US stock, returning 835.1%.

ASSET	YEARS	% RETURN
YPF Sociedad Anonima (YPF)	2022-2025	835.06%
Summit Therapeutics (SMMT)	2022-2025	684.25%
Super Micro Computer (SMCI)	2022-2025	667.99%
Grupo Financiero Galicia SA ADR (GGAL)	2022-2025	612.92%
Vistra Energy (VST)	2022-2025	459.72%
Constellation Energy (CEG)	2022-2025	456.91%
MicroStrategy (MSTR)	2022-2025	425.62%
TechnipFMC (FTI)	2022-2025	418.6%
Fortress Transp & Infra Inv (FTAI)	2022-2025	413.05%
Sprouts Farmers Market LLC (SFM)	2022-2025	397.83%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	367.59%
Fair Isaac (FICO)	2022-2025	319.82%
Howmet Aerospace (HWM)	2022-2025	309.52%
Targa Resources (TRGP)	2022-2025	306.83%
Flex (FLEX)	2022-2025	296.29%
MakeMyTrip (MMYT)	2022-2025	269.68%
NVIDIA (NVDA)	2022-2025	268.45%
Alamos Gold (AGI)	2022-2025	259.87%
Unum (UNM)	2022-2025	258.09%
GE Aerospace (GE)	2022-2025	242.28%
Axon Enterprise (AXON)	2022-2025	241.6%
Texas Pacific Land Trust (TPL)	2022-2025	232.71%
Comfort Systems USA (FIX)	2022-2025	230.97%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2022-2025	221.46%
TKO (TKO)	2022-2025	217.07%

Large-cap stocks are treated as having a market cap of $10B+.