MicroStrategy (MSTR) has had the highest return between 2020 and 2025 by a large-cap US stock, returning 2,280.9%.

ASSET	YEARS	% RETURN
MicroStrategy (MSTR)	2020-2025	2,280.92%
NVIDIA (NVDA)	2020-2025	1,997.14%
GameStop (GME)	2020-2025	1,723.45%
Tesla (TSLA)	2020-2025	1,314.42%
Summit Therapeutics (SMMT)	2020-2025	1,297.5%
Celestica (CLS)	2020-2025	1,273.65%
Antero Resources (AR)	2020-2025	1,214.24%
Super Micro Computer (SMCI)	2020-2025	1,100.84%
Vertiv (VRT)	2020-2025	934.13%
Futu (FUTU)	2020-2025	856.92%
Comfort Systems USA (FIX)	2020-2025	791.11%
Arista Networks (ANET)	2020-2025	785.73%
Axon Enterprise (AXON)	2020-2025	782.77%
Vistra Energy (VST)	2020-2025	770.51%
Constellation Energy (CEG)	2020-2025	735.06%
Palantir Technologies Inc Class A Common Stock (PLTR)	2020-2025	712.2%
Sprouts Farmers Market LLC (SFM)	2020-2025	705.83%
Cloudflare (NET)	2020-2025	696.17%
Crowdstrike (CRWD)	2020-2025	693.26%
Deckers Outdoor (DECK)	2020-2025	688.7%
Broadcom (AVGO)	2020-2025	677.94%
Quanta Services (PWR)	2020-2025	662.5%
Flex (FLEX)	2020-2025	624.57%
Builders FirstSource (BLDR)	2020-2025	574.91%
Eli Lilly and (LLY)	2020-2025	566.42%

Large-cap stocks are treated as having a market cap of $10B+.