MicroStrategy (MSTR) has had the highest return between 2020 and 2025 by a large-cap US stock, returning 2,481.3%.

ASSET	YEARS	% RETURN
MicroStrategy (MSTR)	2020-2025	2,481.28%
NVIDIA (NVDA)	2020-2025	1,767.69%
GameStop (GME)	2020-2025	1,688.93%
Super Micro Computer (SMCI)	2020-2025	1,429.14%
Summit Therapeutics (SMMT)	2020-2025	1,366.56%
Antero Resources (AR)	2020-2025	1,126.74%
Palantir Technologies Inc Class A Common Stock (PLTR)	2020-2025	1,027.8%
Celestica (CLS)	2020-2025	971.6%
Tesla (TSLA)	2020-2025	906.89%
Sprouts Farmers Market LLC (SFM)	2020-2025	766.58%
Futu (FUTU)	2020-2025	758.85%
Crowdstrike (CRWD)	2020-2025	749.25%
Fortress Transp & Infra Inv (FTAI)	2020-2025	719.44%
Comfort Systems USA (FIX)	2020-2025	717.29%
Axon Enterprise (AXON)	2020-2025	715.7%
Vertiv (VRT)	2020-2025	684.95%
Eli Lilly and (LLY)	2020-2025	617.29%
Quanta Services (PWR)	2020-2025	608.66%
Cloudflare (NET)	2020-2025	601.86%
Broadcom (AVGO)	2020-2025	595.81%
Vistra Energy (VST)	2020-2025	526.36%
Flex (FLEX)	2020-2025	506.45%
Arista Networks (ANET)	2020-2025	506.07%
Constellation Energy (CEG)	2020-2025	504.63%
Texas Pacific Land Trust (TPL)	2020-2025	464.14%

Large-cap stocks are treated as having a market cap of $10B+.