MicroStrategy (MSTR) has had the highest return between 2020 and 2025 by a large-cap US stock, returning 2,250.3%.

ASSET	YEARS	% RETURN
MicroStrategy (MSTR)	2020-2025	2,250.32%
NVIDIA (NVDA)	2020-2025	1,942.67%
Super Micro Computer (SMCI)	2020-2025	1,649.27%
GameStop (GME)	2020-2025	1,568.4%
Antero Resources (AR)	2020-2025	1,330.9%
Summit Therapeutics (SMMT)	2020-2025	1,193.13%
Celestica (CLS)	2020-2025	1,103.13%
Futu (FUTU)	2020-2025	953.5%
Tesla (TSLA)	2020-2025	883.71%
Palantir Technologies Inc Class A Common Stock (PLTR)	2020-2025	867.5%
Fortress Transp & Infra Inv (FTAI)	2020-2025	798.15%
Vertiv (VRT)	2020-2025	745.79%
Comfort Systems USA (FIX)	2020-2025	679.88%
Axon Enterprise (AXON)	2020-2025	673.47%
Sprouts Farmers Market LLC (SFM)	2020-2025	649.97%
Crowdstrike (CRWD)	2020-2025	644.83%
Cloudflare (NET)	2020-2025	618.85%
Eli Lilly and (LLY)	2020-2025	601.36%
Broadcom (AVGO)	2020-2025	591.97%
Quanta Services (PWR)	2020-2025	586.35%
Arista Networks (ANET)	2020-2025	580.75%
Vistra Energy (VST)	2020-2025	567.44%
Flex (FLEX)	2020-2025	544.33%
Constellation Energy (CEG)	2020-2025	519.9%
Carrier Global (CARR)	2020-2025	503.72%

Large-cap stocks are treated as having a market cap of $10B+.