NVIDIA (NVDA) had the highest return between 2020 and 2024 by a large-cap US stock, returning 2,159.1%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2020-2024	2,159.14%
GameStop (GME)	2020-2024	1,941.69%
MicroStrategy (MSTR)	2020-2024	1,927.58%
Tesla (TSLA)	2020-2024	1,327%
Super Micro Computer (SMCI)	2020-2024	1,177.99%
Antero Resources (AR)	2020-2024	1,117.01%
Fortress Transp & Infra Inv (FTAI)	2020-2024	1,022.49%
Summit Therapeutics (SMMT)	2020-2024	1,015.31%
Celestica (CLS)	2020-2024	1,010.71%
Vertiv (VRT)	2020-2024	925.19%
Comfort Systems USA (FIX)	2020-2024	770.98%
Arista Networks (ANET)	2020-2024	759.82%
Broadcom (AVGO)	2020-2024	736.3%
Axon Enterprise (AXON)	2020-2024	702.92%
Quanta Services (PWR)	2020-2024	678.92%
Futu (FUTU)	2020-2024	663.99%
Palantir Technologies Inc Class A Common Stock (PLTR)	2020-2024	656.3%
Deckers Outdoor (DECK)	2020-2024	617.93%
Crowdstrike (CRWD)	2020-2024	583.91%
Vistra Energy (VST)	2020-2024	580.75%
Flex (FLEX)	2020-2024	561.03%
Sprouts Farmers Market LLC (SFM)	2020-2024	555.34%
Eli Lilly and (LLY)	2020-2024	524.95%
Cloudflare (NET)	2020-2024	524.59%
Carrier Global (CARR)	2020-2024	506.38%

Large-cap stocks are treated as having a market cap of $10B+.