Netflix (NFLX) had the highest return between 2012 and 2018 by a large-cap US stock, returning 2,565.9%.

ASSET	YEARS	% RETURN
Netflix (NFLX)	2012-2018	2,565.94%
Genmab A-S (GMAB)	2012-2018	2,419.11%
Texas Pacific Land Trust (TPL)	2012-2018	1,300.8%
DexCom (DXCM)	2012-2018	1,158.4%
Tesla (TSLA)	2012-2018	1,049.99%
NVIDIA (NVDA)	2012-2018	909.64%
TKO (TKO)	2012-2018	888.96%
Broadcom (AVGO)	2012-2018	885.46%
Illumina (ILMN)	2012-2018	867.51%
Burlington Stores (BURL)	2012-2018	856.88%
Alnylam Pharmaceuticals (ALNY)	2012-2018	775.27%
Align Technology (ALGN)	2012-2018	763.99%
Amazon (AMZN)	2012-2018	753.93%
Huazhu (HTHT)	2012-2018	738.14%
Axon Enterprise (AXON)	2012-2018	734.92%
Monolithic Power Systems (MPWR)	2012-2018	731.35%
Domino's Pizza Inc Common Stock (DPZ)	2012-2018	728.26%
Booz Allen Hamilton (BAH)	2012-2018	722.87%
Neurocrine Biosciences (NBIX)	2012-2018	717.05%
Constellation Brands Inc Class A (STZ)	2012-2018	699.14%
Adobe Systems (ADBE)	2012-2018	688.29%
ServiceNow (NOW)	2012-2018	649.68%
ICON (ICLR)	2012-2018	645.16%
Take-Two Interactive Software (TTWO)	2012-2018	644.32%
HCA (HCA)	2012-2018	621.1%

Large-cap stocks are treated as having a market cap of $10B+.