Regeneron Pharmaceuticals (REGN) had the highest return between 2010 and 2015 by a large-cap US stock, returning 2,139.6%.

ASSET	YEARS	% RETURN
Regeneron Pharmaceuticals (REGN)	2010-2015	2,139.56%
Neurocrine Biosciences (NBIX)	2010-2015	1,942.24%
Cheniere Energy (LNG)	2010-2015	1,389.95%
Domino's Pizza Inc Common Stock (DPZ)	2010-2015	1,363.15%
Netflix (NFLX)	2010-2015	1,342.12%
Tesla (TSLA)	2010-2015	1,163.18%
Incyte (INCY)	2010-2015	1,076.25%
Manhattan Associates (MANH)	2010-2015	987.88%
DexCom (DXCM)	2010-2015	897.56%
Ulta Beauty (ULTA)	2010-2015	872.8%
Western Alliance Bancorporation (WAL)	2010-2015	821.85%
Constellation Brands Inc Class A (STZ)	2010-2015	795.84%
American Airlines (AAL)	2010-2015	786.97%
Tyler Technologies (TYL)	2010-2015	769.43%
Broadcom (AVGO)	2010-2015	760.74%
U-Haul (UHAL)	2010-2015	729.02%
Genmab A-S (GMAB)	2010-2015	702.51%
Monster Beverage (MNST)	2010-2015	670.63%
United Rentals (URI)	2010-2015	631.25%
Transdigm (TDG)	2010-2015	590.44%
Acuity Brands (AYI)	2010-2015	581.38%
Tractor Supply (TSCO)	2010-2015	575.24%
NXP Semiconductors (NXPI)	2010-2015	548.08%
O’Reilly Automotive (ORLY)	2010-2015	545.82%
Illumina (ILMN)	2010-2015	516.81%

Large-cap stocks are treated as having a market cap of $10B+.