YPF Sociedad Anonima (YPF) has had the highest return between 2022 and 2025 by a large-cap US stock, returning 1,044.4%.

ASSET	YEARS	% RETURN
YPF Sociedad Anonima (YPF)	2022-2025	1,044.42%
Grupo Financiero Galicia SA ADR (GGAL)	2022-2025	796.19%
Celestica (CLS)	2022-2025	770.02%
Vistra Energy (VST)	2022-2025	662.05%
Super Micro Computer (SMCI)	2022-2025	647.14%
Summit Therapeutics (SMMT)	2022-2025	603.98%
Fortress Transp & Infra Inv (FTAI)	2022-2025	589.17%
Constellation Energy (CEG)	2022-2025	583.1%
MicroStrategy (MSTR)	2022-2025	516.88%
Credo Technology (CRDO)	2022-2025	498.26%
Reddit (RDDT)	2022-2025	422.76%
TechnipFMC (FTI)	2022-2025	420.5%
Vertiv (VRT)	2022-2025	400.54%
NVIDIA (NVDA)	2022-2025	385.32%
Flex (FLEX)	2022-2025	378.46%
Comfort Systems USA (FIX)	2022-2025	357.48%
Sprouts Farmers Market LLC (SFM)	2022-2025	353.67%
Fair Isaac (FICO)	2022-2025	349.79%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	335.13%
MakeMyTrip (MMYT)	2022-2025	318.43%
Axon Enterprise (AXON)	2022-2025	283.82%
Targa Resources (TRGP)	2022-2025	281.48%
EMCOR (EME)	2022-2025	275.15%
Broadcom (AVGO)	2022-2025	273.36%
Applovin (APP)	2022-2025	269.11%

Large-cap stocks are treated as having a market cap of $10B+.