Moderna (MRNA) had the highest return between 2019 and 2022 by a large-cap US stock, returning 1,103.1%.

ASSET	YEARS	% RETURN
Moderna (MRNA)	2019-2022	1,103.08%
BioNTech SE (BNTX)	2019-2022	822.48%
GameStop (GME)	2019-2022	513.21%
Builders FirstSource (BLDR)	2019-2022	508.63%
Tesla (TSLA)	2019-2022	503.63%
Super Micro Computer (SMCI)	2019-2022	495.36%
Quanta Services (PWR)	2019-2022	387.42%
Kinsale Capital (KNSL)	2019-2022	381.97%
Texas Pacific Land Trust (TPL)	2019-2022	374.86%
Sea (SE)	2019-2022	367.9%
KLA-Tencor (KLAC)	2019-2022	360.51%
Ares Management (ARES)	2019-2022	355.87%
NVIDIA (NVDA)	2019-2022	350.77%
Dick’s Sporting Goods (DKS)	2019-2022	349.92%
United Microelectronics (UMC)	2019-2022	348.67%
MACOM Technology Solutions (MTSI)	2019-2022	344.46%
TFI International (TFII)	2019-2022	315.98%
Medpace (MEDP)	2019-2022	307.38%
Trade Desk (TTD)	2019-2022	300.77%
Freeport-McMoran Copper & Gold (FCX)	2019-2022	297.04%
argenx NV ADR (ARGX)	2019-2022	288.15%
Synopsys (SNPS)	2019-2022	287.63%
DexCom (DXCM)	2019-2022	287.11%
ON Semiconductor (ON)	2019-2022	286.43%
Summit Therapeutics (SMMT)	2019-2022	286.36%

Large-cap stocks are treated as having a market cap of $10B+.