EXACT Sciences (EXAS) had the highest return between 2017 and 2017 by a large-cap US stock, returning 286%.

ASSET	YEARS	% RETURN
EXACT Sciences (EXAS)	2017-2017	286.04%
argenx NV ADR (ARGX)	2017-2017	252.74%
Alnylam Pharmaceuticals (ALNY)	2017-2017	233.03%
Roku (ROKU)	2017-2017	228.14%
Block (SQ)	2017-2017	150.87%
Arista Networks (ANET)	2017-2017	141.52%
Grupo Financiero Galicia SA ADR (GGAL)	2017-2017	140.14%
Shopify (SHOP)	2017-2017	133.36%
NRG Energy (NRG)	2017-2017	132.56%
Insmed (INSM)	2017-2017	132.17%
Floor & Decor (FND)	2017-2017	131.81%
Align Technology (ALGN)	2017-2017	130.27%
Take-Two Interactive Software (TTWO)	2017-2017	122.45%
New Oriental Education & Technology (EDU)	2017-2017	121.05%
NVR (NVR)	2017-2017	112.62%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2017-2017	111.59%
XPO Logistics (XPO)	2017-2017	109.35%
First Solar (FSLR)	2017-2017	107.05%
Vertex Pharmaceuticals (VRTX)	2017-2017	101.34%
Neurocrine Biosciences (NBIX)	2017-2017	100.03%
MercadoLibre (MELI)	2017-2017	98.47%
STMicroelectronics NV ADR (STM)	2017-2017	98.18%
Sarepta Therapeutics (SRPT)	2017-2017	96.26%
Builders FirstSource (BLDR)	2017-2017	94.21%
Boeing (BA)	2017-2017	93.94%

Large-cap stocks are treated as having a market cap of $10B+.