NVIDIA (NVDA) had the highest return between 2015 and 2016 by a large-cap US stock, returning 444.2%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2015-2016	444.21%
Advanced Micro Devices (AMD)	2015-2016	320%
Centrais Electricas Brasileiras (EBR)	2015-2016	228.23%
Genmab A-S (GMAB)	2015-2016	176.38%
Centrais Elétricas Brasileiras SA - Eletrobrás (EBR.B)	2015-2016	175.5%
Texas Pacific Land Trust (TPL)	2015-2016	155.24%
Netflix (NFLX)	2015-2016	151.87%
Amazon (AMZN)	2015-2016	139.9%
NetEase (NTES)	2015-2016	122.18%
Coherent (COHR)	2015-2016	115.48%
T-Mobile US (TMUS)	2015-2016	112.21%
Wix (WIX)	2015-2016	110.14%
New Oriental Education & Technology (EDU)	2015-2016	108.39%
Banco Santander Brasil SA ADR (BSBR)	2015-2016	107.63%
Coca-Cola Consolidated (COKE)	2015-2016	104.17%
Martin Marietta Materials (MLM)	2015-2016	102.34%
Ulta Beauty (ULTA)	2015-2016	98.97%
Comfort Systems USA (FIX)	2015-2016	97.88%
Permian Resources (PR)	2015-2016	97.2%
Logitech International (LOGI)	2015-2016	95.63%
Ubiquiti Networks (UI)	2015-2016	92.73%
Vulcan Materials (VMC)	2015-2016	90.68%
Steel Dynamics (STLD)	2015-2016	89.02%
Danaher (DHR)	2015-2016	88.98%
Sarepta Therapeutics (SRPT)	2015-2016	88.13%

Large-cap stocks are treated as having a market cap of $10B+.