Carvana (CVNA) has had the highest return between 2023 and 2025 by a large-cap US stock, returning 3,777.3%.

ASSET	YEARS	% RETURN
Carvana (CVNA)	2023-2025	3,777.34%
Applovin (APP)	2023-2025	2,738.58%
MicroStrategy (MSTR)	2023-2025	1,920.11%
Palantir Technologies Inc Class A Common Stock (PLTR)	2023-2025	1,227.51%
Celestica (CLS)	2023-2025	710.78%
NVIDIA (NVDA)	2023-2025	705.46%
Spotify Technology (SPOT)	2023-2025	629.68%
Grupo Financiero Galicia SA ADR (GGAL)	2023-2025	601.96%
Fortress Transp & Infra Inv (FTAI)	2023-2025	565.12%
Vertiv (VRT)	2023-2025	543.84%
Vistra Energy (VST)	2023-2025	464.46%
Aurora Innovation (AUR)	2023-2025	448.82%
Coinbase Global (COIN)	2023-2025	417.84%
Robinhood Markets (HOOD)	2023-2025	408.72%
Super Micro Computer (SMCI)	2023-2025	404.81%
Facebook (META)	2023-2025	394.83%
Affirm (AFRM)	2023-2025	378.64%
Summit Therapeutics (SMMT)	2023-2025	363.82%
Royal Caribbean Cruises (RCL)	2023-2025	337.68%
Sprouts Farmers Market LLC (SFM)	2023-2025	334.75%
Duolingo (DUOL)	2023-2025	313.58%
YPF Sociedad Anonima (YPF)	2023-2025	291.98%
GE Aerospace (GE)	2023-2025	290.26%
Insmed (INSM)	2023-2025	286.53%
DoorDash, Inc Class A Common Stock (DASH)	2023-2025	279.87%

Large-cap stocks are treated as having a market cap of $10B+.