Biogen (BIIB) had the highest return in September 2022 by a large-cap US stock, returning 37.1%.

ASSET	MONTH	% RETURN
Biogen (BIIB)	September 2022	37.08%
Wix (WIX)	September 2022	26.42%
Regeneron Pharmaceuticals (REGN)	September 2022	19.26%
Kinross Gold (KGC)	September 2022	17.13%
Penumbra (PEN)	September 2022	16.91%
Aspen Technology (AZPN)	September 2022	13.64%
YPF Sociedad Anonima (YPF)	September 2022	13.53%
Trip Group Ltd ADR (TCOM)	September 2022	9.81%
Vale SA ADR (VALE)	September 2022	9.36%
Hubbell (HUBB)	September 2022	8.8%
Medpace (MEDP)	September 2022	7.98%
Wheaton Precious Metals (WPM)	September 2022	7.83%
Robinhood Markets (HOOD)	September 2022	7.45%
Eli Lilly and (LLY)	September 2022	7.43%
Palantir Technologies Inc Class A Common Stock (PLTR)	September 2022	6.83%
Aurora Innovation (AUR)	September 2022	6.76%
Netflix (NFLX)	September 2022	6.67%
First Solar (FSLR)	September 2022	6.22%
AngloGold Ashanti (AU)	September 2022	5.98%
Joint Stock Company Kaspikz American Depository Shares (KSPI)	September 2022	5.98%
Barrick Gold (GOLD)	September 2022	5.8%
Haleon (HLN)	September 2022	5.73%
Cheniere Energy Partners (CQP)	September 2022	5.52%
Bristol-Myers Squibb (BMY)	September 2022	5.49%
CyberArk Software (CYBR)	September 2022	5.29%

Large-cap stocks are treated as having a market cap of $10B+.