Monster Beverage (MNST) had the highest return between 2000 and 2008 by a large-cap US stock, returning 6,165%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2000-2008	6,165.02%
Clean Harbors (CLH)	2000-2008	5,105.12%
Deckers Outdoor (DECK)	2000-2008	2,943.35%
Banco Bradesco SA ADR (BBD)	2000-2008	1,817.93%
Gilead Sciences (GILD)	2000-2008	1,332.38%
DaVita HealthCare Partners (DVA)	2000-2008	1,001.56%
Southern Copper (SCCO)	2000-2008	984.01%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2000-2008	935.64%
ANSYS (ANSS)	2000-2008	925.37%
Vale SA ADR (VALE)	2000-2008	881.72%
NVR (NVR)	2000-2008	855.5%
Stifel Financial (SF)	2000-2008	852.27%
Axon Enterprise (AXON)	2000-2008	805.19%
Tractor Supply (TSCO)	2000-2008	799.94%
Hologic (HOLX)	2000-2008	799.39%
Old Dominion Freight Line (ODFL)	2000-2008	793.39%
Elbit Systems (ESLT)	2000-2008	777.65%
BlackRock (BLK)	2000-2008	736.09%
Tapestry (TPR)	2000-2008	730.83%
Ambev SA ADR (ABEV)	2000-2008	715.07%
British American Tobacco (BTI)	2000-2008	708.61%
EOG Resources (EOG)	2000-2008	704.58%
W R Berkley (WRB)	2000-2008	693.19%
JB Hunt Transport Services (JBHT)	2000-2008	682%
Cameco (CCJ)	2000-2008	668.89%

Large-cap stocks are treated as having a market cap of $10B+.