Monster Beverage (MNST) had the highest return between 1999 and 2005 by a large-cap US stock, returning 2,837.2%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	1999-2005	2,837.21%
Cheniere Energy (LNG)	1999-2005	2,014.78%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2005	1,943.64%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2005	1,869.73%
Clean Harbors (CLH)	1999-2005	1,672.92%
Laboratory Corporation of America (LH)	1999-2005	1,466.69%
Logitech International (LOGI)	1999-2005	1,459.03%
NVR (NVR)	1999-2005	1,372.08%
Banco Bradesco SA ADR (BBD)	1999-2005	1,257.53%
Qualcomm (QCOM)	1999-2005	1,242.52%
Tapestry (TPR)	1999-2005	1,233.64%
Deckers Outdoor (DECK)	1999-2005	1,199.24%
Pool (POOL)	1999-2005	1,166.76%
Cameco (CCJ)	1999-2005	1,114.93%
Axon Enterprise (AXON)	1999-2005	1,093.23%
Quest Diagnostics (DGX)	1999-2005	1,076.64%
UnitedHealth (UNH)	1999-2005	1,039.43%
Gilead Sciences (GILD)	1999-2005	925.79%
Southern Copper (SCCO)	1999-2005	875.92%
CME (CME)	1999-2005	866.49%
Infosys Ltd ADR (INFY)	1999-2005	862.06%
Valero Energy (VLO)	1999-2005	860.01%
Neurocrine Biosciences (NBIX)	1999-2005	796.14%
Coherent (COHR)	1999-2005	793.49%
EOG Resources (EOG)	1999-2005	787.74%

Large-cap stocks are treated as having a market cap of $10B+.