Booking (BKNG) had the highest return between 2005 and 2010 by a large-cap US stock, returning 1,584.4%.

ASSET	YEARS	% RETURN
Booking (BKNG)	2005-2010	1,584.45%
Banco Bradesco SA ADR (BBD)	2005-2010	1,375.86%
Baidu (BIDU)	2005-2010	1,362.58%
Netflix (NFLX)	2005-2010	1,307.82%
Illumina (ILMN)	2005-2010	1,244.8%
Wheaton Precious Metals (WPM)	2005-2010	1,223.37%
Ambev SA ADR (ABEV)	2005-2010	1,172.13%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2005-2010	1,052.42%
Monster Beverage (MNST)	2005-2010	1,018.54%
Apple (AAPL)	2005-2010	895.87%
Southern Copper (SCCO)	2005-2010	869.87%
Credicorp (BAP)	2005-2010	793.85%
CF Industries (CF)	2005-2010	749.97%
Salesforce (CRM)	2005-2010	704.39%
Trip Group Ltd ADR (TCOM)	2005-2010	616.28%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2010	597.58%
Intuitive Surgical (ISRG)	2005-2010	544.06%
TechnipFMC (FTI)	2005-2010	492.77%
Agnico Eagle Mines (AEM)	2005-2010	471.35%
Tenaris SA ADR (TS)	2005-2010	469.87%
Cummins (CMI)	2005-2010	468.96%
Mastercard (MA)	2005-2010	464.2%
Clean Harbors (CLH)	2005-2010	453.16%
Vale SA ADR (VALE)	2005-2010	444.97%
F5 Networks (FFIV)	2005-2010	431.27%

Large-cap stocks are treated as having a market cap of $10B+.