Monster Beverage (MNST) had the highest return in the 2000s by a large-cap US stock, returning 7,074.9%.

ASSET	DECADE	% RETURN
Monster Beverage (MNST)	2000s	7,074.89%
Clean Harbors (CLH)	2000s	4,790.88%
Banco Bradesco SA ADR (BBD)	2000s	4,320.85%
Deckers Outdoor (DECK)	2000s	3,775.93%
Vale SA ADR (VALE)	2000s	2,310.13%
Southern Copper (SCCO)	2000s	2,157.79%
CarMax (KMX)	2000s	2,055.56%
Ambev SA ADR (ABEV)	2000s	1,835.22%
Intuitive Surgical (ISRG)	2000s	1,585.81%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2000s	1,546.87%
ANSYS (ANSS)	2000s	1,497.79%
Tenaris SA ADR (TS)	2000s	1,470.66%
NVR (NVR)	2000s	1,388.4%
BlackRock (BLK)	2000s	1,376.69%
Tapestry (TPR)	2000s	1,372.2%
Cameco (CCJ)	2000s	1,351.72%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2000s	1,279.82%
Tractor Supply (TSCO)	2000s	1,218.71%
DaVita HealthCare Partners (DVA)	2000s	1,205.33%
Elbit Systems (ESLT)	2000s	1,169.67%
Stifel Financial (SF)	2000s	1,130.37%
Trip Group Ltd ADR (TCOM)	2000s	1,118.96%
Gilead Sciences (GILD)	2000s	1,111.95%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2000s	1,105.3%
EOG Resources (EOG)	2000s	1,085.54%

Large-cap stocks are treated as having a market cap of $10B+.