Netflix (NFLX) had the highest return between 2008 and 2016 by a US stock in the S&P 500 (GSPC), returning 3,162.8%.

ASSET	YEARS	% RETURN
Netflix (NFLX)	2008-2016	3,162.79%
Regeneron Pharmaceuticals (REGN)	2008-2016	1,428.27%
Ulta Beauty (ULTA)	2008-2016	1,416.43%
Domino's Pizza Inc Common Stock (DPZ)	2008-2016	1,265.93%
MarketAxess (MKTX)	2008-2016	1,212.88%
Booking (BKNG)	2008-2016	1,155.73%
Broadcom (AVGO)	2008-2016	1,080.43%
Ross Stores (ROST)	2008-2016	1,032.94%
Tesla (TSLA)	2008-2016	1,024.65%
Tyler Technologies (TYL)	2008-2016	1,011.92%
Transdigm (TDG)	2008-2016	937.07%
Incyte (INCY)	2008-2016	898.71%
Smith AO (AOS)	2008-2016	838.33%
Skyworks Solutions (SWKS)	2008-2016	810.62%
Tractor Supply (TSCO)	2008-2016	810.04%
Dollar Tree (DLTR)	2008-2016	793.29%
O’Reilly Automotive (ORLY)	2008-2016	762.48%
Old Dominion Freight Line (ODFL)	2008-2016	750.33%
Charter Communications (CHTR)	2008-2016	722.63%
Edwards Lifesciences (EW)	2008-2016	719.75%
Amazon (AMZN)	2008-2016	686.44%
NXP Semiconductors (NXPI)	2008-2016	653.92%
Texas Pacific Land Trust (TPL)	2008-2016	591.38%
Constellation Brands Inc Class A (STZ)	2008-2016	561.1%
DexCom (DXCM)	2008-2016	559.67%