Axon Enterprise (AXON) had the highest return between 1999 and 2003 by a US stock with a market cap of $10B+, returning 1,076.8%.

ASSET	YEARS	% RETURN
Axon Enterprise (AXON)	1999-2003	1,076.79%
Laboratory Corporation of America (LH)	1999-2003	975%
NVR (NVR)	1999-2003	877.2%
Deckers Outdoor (DECK)	1999-2003	864.35%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2003	794.2%
Qualcomm (QCOM)	1999-2003	728.02%
Quest Diagnostics (DGX)	1999-2003	723.79%
Primo Brands (PRMB)	1999-2003	672.71%
Tapestry (TPR)	1999-2003	655.03%
Pool (POOL)	1999-2003	629.24%
Logitech International (LOGI)	1999-2003	608.79%
Genesis Healthcare (GEN)	1999-2003	541.81%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2003	539.72%
Tractor Supply (TSCO)	1999-2003	536.43%
Royal Gold (RGLD)	1999-2003	482.57%
Southern Copper (SCCO)	1999-2003	475.06%
Gilead Sciences (GILD)	1999-2003	468.56%
CarMax (KMX)	1999-2003	462.36%
Teva Pharma Industries Ltd ADR (TEVA)	1999-2003	460.07%
Infosys Ltd ADR (INFY)	1999-2003	455.24%
Clean Harbors (CLH)	1999-2003	448.31%
Lam Research (LRCX)	1999-2003	434.6%
UnitedHealth (UNH)	1999-2003	433.2%
Ryanair Holdings PLC ADR (RYAAY)	1999-2003	429.76%
Trimble (TRMB)	1999-2003	409.29%