Clean Harbors (CLH) had the highest return between 2000 and 2002 by a large-cap US stock, returning 1,176.7%.

ASSET	YEARS	% RETURN
Clean Harbors (CLH)	2000-2002	1,176.67%
CarMax (KMX)	2000-2002	694.67%
Royal Gold (RGLD)	2000-2002	614.67%
NVR (NVR)	2000-2002	583.77%
Tractor Supply (TSCO)	2000-2002	368.12%
Altria (MO)	2000-2002	273.52%
Quest Diagnostics (DGX)	2000-2002	269.33%
DaVita HealthCare Partners (DVA)	2000-2002	265.48%
CoreSite Realty (COR)	2000-2002	251.06%
Brown & Brown (BRO)	2000-2002	249.22%
Primo Brands (PRMB)	2000-2002	239.43%
Gold Fields Ltd ADR (GFI)	2000-2002	235.48%
Tapestry (TPR)	2000-2002	229.21%
Lennar (LEN)	2000-2002	221.53%
UnitedHealth (UNH)	2000-2002	214.82%
Renaissancere (RNR)	2000-2002	210.24%
Manhattan Associates (MANH)	2000-2002	206.52%
Ryanair Holdings PLC ADR (RYAAY)	2000-2002	188.74%
EMCOR (EME)	2000-2002	188.49%
W R Berkley (WRB)	2000-2002	188.45%
Lockheed Martin (LMT)	2000-2002	172.27%
Ball (BALL)	2000-2002	170.83%
Old Dominion Freight Line (ODFL)	2000-2002	164.18%
Enterprise Products Partners (EPD)	2000-2002	157.03%
Laboratory Corporation of America (LH)	2000-2002	152.1%

Large-cap stocks are treated as having a market cap of $10B+.