Advanced Micro Devices (AMD) had the highest return between 2016 and 2022 by a US stock with a market cap of $40B+, returning 2,238.3%.

ASSET	YEARS	% RETURN
Advanced Micro Devices (AMD)	2016-2022	2,238.27%
NVIDIA (NVDA)	2016-2022	1,753.69%
Shopify (SHOP)	2016-2022	1,265.46%
Axon Enterprise (AXON)	2016-2022	876.06%
Vale SA ADR (VALE)	2016-2022	708.6%
Cadence Design Systems (CDNS)	2016-2022	703.2%
Tesla (TSLA)	2016-2022	700.84%
Fortinet (FTNT)	2016-2022	700.43%
MercadoLibre (MELI)	2016-2022	658.11%
Ares Management (ARES)	2016-2022	650.95%
Old Dominion Freight Line (ODFL)	2016-2022	648.98%
Quanta Services (PWR)	2016-2022	624.41%
Synopsys (SNPS)	2016-2022	607.8%
MSCI (MSCI)	2016-2022	604.51%
ASML Holding NV ADR (ASML)	2016-2022	573.83%
Copart (CPRT)	2016-2022	547.87%
KLA-Tencor (KLAC)	2016-2022	542.85%
Fair Isaac (FICO)	2016-2022	541.91%
Deere (DE)	2016-2022	540.81%
Arista Networks (ANET)	2016-2022	523.51%
Apollo Global Management LLC Class A (APO)	2016-2022	521%
Danaher (DHR)	2016-2022	520.96%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2016-2022	510.49%
Freeport-McMoran Copper & Gold (FCX)	2016-2022	508.37%
Lam Research (LRCX)	2016-2022	503.18%