Helport AI Limited Ordinary Shares (HPAI) had the highest return between 2015 and 2021 by a US stock, returning 9,759,900%.

ASSET	YEARS	% RETURN
Helport AI Limited Ordinary Shares (HPAI)	2015-2021	9,759,900%
Clene (CLNN)	2015-2021	6,833,233.33%
Crown Electrokinetics (CRKN)	2015-2021	3,989,900%
Ainos (AIMD)	2015-2021	1,105,163.16%
XORTX Therapeutics (XRTX)	2015-2021	1,044,239.62%
authID (AUID)	2015-2021	897,820%
Bragg Gaming (BRAG)	2015-2021	838,233.33%
Scinai Immunotherapeutics (SCNI)	2015-2021	469,900%
Zhihu Inc ADR (ZH)	2015-2021	455,242.47%
Fresh2 (FRES)	2015-2021	433,292.54%
Luokung Technology (LKCO)	2015-2021	348,101.44%
Proficient Auto Logistics, Inc Common Stock (PAL)	2015-2021	282,785.43%
Immatics (IMTX)	2015-2021	268,700%
KWESST Micro Systems Inc Common Stock (KWE)	2015-2021	86,695.35%
Connexa Sports Technologies (YYAI)	2015-2021	68,700%
Freedom (FRHC)	2015-2021	55,812%
Applied Digital (APLD)	2015-2021	43,095.88%
Skye Bioscience, Inc Common Stock (SKYE)	2015-2021	41,835.48%
NAYA Biosciences (NAYA)	2015-2021	25,515.38%
eXp World (EXPI)	2015-2021	22,770.01%
Alarum Technologies (ALAR)	2015-2021	20,843.95%
Avalon GloboCare (ALBT)	2015-2021	17,471.43%
Celsius (CELH)	2015-2021	14,811.04%
Metalla Royalty & Streaming (MTA)	2015-2021	14,803.04%
HIVE Blockchain Technologies (HIVE)	2015-2021	13,100%