Faraday Future Intelligent Electric (FFIE) had the highest return between 2000 and 2021 by a US stock, returning 529,143.5%.

ASSET	YEARS	% RETURN
Faraday Future Intelligent Electric (FFIE)	2000-2021	529,143.52%
Ainos (AIMD)	2000-2021	302,784.62%
Immatics (IMTX)	2000-2021	268,700%
Know Labs (KNW)	2000-2021	172,673.54%
Perspective Therapeutics (CATX)	2000-2021	129,900%
Monster Beverage (MNST)	2000-2021	107,568.16%
MEDIFAST (MED)	2000-2021	72,525.63%
Netflix (NFLX)	2000-2021	51,996.16%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2000-2021	51,684.21%
Deckers Outdoor (DECK)	2000-2021	41,773.59%
Old Dominion Freight Line (ODFL)	2000-2021	38,695.93%
NVIDIA (NVDA)	2000-2021	32,454.66%
Texas Pacific Land Trust (TPL)	2000-2021	29,691.35%
AquaBounty Technologies (AQB)	2000-2021	29,066.67%
Tesla (TSLA)	2000-2021	27,709.27%
Tractor Supply (TSCO)	2000-2021	27,186.91%
Axon Enterprise (AXON)	2000-2021	26,815.82%
Apple (AAPL)	2000-2021	22,018.67%
Middleby (MIDD)	2000-2021	21,798.72%
Pioneer Power Solutions (PPSI)	2000-2021	21,670.38%
Alarum Technologies (ALAR)	2000-2021	20,843.95%
Credit Acceptance (CACC)	2000-2021	18,238.13%
Intuitive Surgical (ISRG)	2000-2021	17,865.9%
RadNet (RDNT)	2000-2021	17,611.76%
Avalon GloboCare (ALBT)	2000-2021	17,471.43%