Since 2021, the Los Angeles Dodgers have the most wins by a team, with 431 wins.

Interpreted as:

most regular-season wins by an MLB team since 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	431	242	.640	673	22,832	3,541	5,782	1,199	103	972	3,416	2,553	320	5,687	415	89	25,981	10,103	2,274	50	226	123	392	.253	.334	.442	.776
2	Braves	392	279	.584	671	22,743	3,322	5,764	1,162	70	1,034	3,194	2,126	264	5,917	360	100	25,343	10,168	2,266	46	164	80	447	.253	.322	.447	.769
3	Astros	392	279	.584	671	22,887	3,259	5,912	1,155	67	866	3,134	2,173	274	5,015	356	100	25,573	9,799	2,088	48	191	93	526	.258	.327	.428	.756
4	Yankees	382	291	.568	673	22,364	3,143	5,349	942	54	973	2,994	2,570	243	5,867	375	113	25,400	9,318	1,969	47	176	98	549	.239	.322	.417	.739
5	Brewers	379	294	.563	673	22,477	3,095	5,376	1,043	88	780	2,952	2,434	283	6,002	558	127	25,411	8,935	1,911	65	152	88	472	.239	.319	.398	.717
6	Rays	375	297	.558	672	22,611	3,089	5,506	1,151	103	760	2,934	2,169	307	6,032	549	178	25,265	9,143	2,014	29	149	62	388	.244	.316	.404	.721
7	Phillies	367	306	.545	673	22,780	3,172	5,733	1,131	110	842	3,044	2,204	257	5,822	497	108	25,495	9,610	2,083	81	173	100	455	.252	.322	.422	.744
8	Mariners	366	306	.545	672	22,364	2,930	5,156	999	57	825	2,808	2,353	404	6,337	438	120	25,318	8,744	1,881	41	156	55	424	.231	.313	.391	.704
9	Giants	363	310	.539	673	22,562	3,010	5,388	1,094	91	801	2,879	2,305	297	6,090	273	74	25,410	9,067	1,986	72	174	95	468	.239	.315	.402	.717
10	Mets	360	313	.535	673	22,396	2,998	5,491	1,051	87	793	2,866	2,127	416	5,512	357	88	25,171	9,095	1,931	83	149	77	473	.245	.320	.406	.726
11	Padres	360	313	.535	673	22,599	3,049	5,611	1,119	72	752	2,916	2,355	244	5,208	441	126	25,481	9,130	1,943	110	173	104	498	.248	.324	.404	.728
12	Blue Jays	358	315	.532	673	22,835	3,126	5,849	1,209	71	819	3,000	2,136	265	5,177	337	110	25,432	9,657	2,099	41	155	61	522	.256	.325	.423	.748
13	Guardians	354	317	.528	671	22,492	2,881	5,504	1,090	102	667	2,730	1,918	296	5,035	544	131	24,970	8,799	1,859	74	190	127	455	.245	.310	.391	.701
14	Cardinals	347	326	.516	673	22,743	2,989	5,660	1,123	77	792	2,867	2,151	300	5,413	398	109	25,450	9,313	1,992	78	178	78	445	.249	.320	.409	.729
15	Red Sox	343	331	.509	674	23,066	3,208	5,923	1,383	87	776	3,061	2,070	277	5,946	378	116	25,626	9,808	2,246	40	173	98	473	.257	.323	.425	.748
16	Orioles	336	335	.501	671	22,660	3,027	5,537	1,141	105	815	2,903	1,997	269	5,763	372	107	25,152	9,333	2,061	53	173	51	403	.244	.311	.412	.723
17	Twins	329	343	.490	672	22,673	3,030	5,525	1,154	85	841	2,885	2,180	343	5,915	259	77	25,406	9,372	2,080	39	171	57	503	.244	.317	.413	.731
18	Cubs	327	347	.485	674	22,593	3,080	5,508	1,061	124	773	2,934	2,233	333	6,014	520	144	25,422	9,136	1,958	95	168	66	455	.244	.319	.404	.723
19	Tigers	322	351	.478	673	22,511	2,709	5,310	991	146	641	2,604	1,943	213	6,089	305	98	24,888	8,516	1,778	48	173	41	430	.236	.301	.378	.679
20	Reds	316	357	.470	673	22,463	3,044	5,419	1,094	98	778	2,907	2,150	387	6,034	517	158	25,240	9,043	1,970	86	154	45	458	.241	.316	.403	.719
21	Diamondbacks	313	359	.466	672	22,603	3,144	5,541	1,164	139	728	2,980	2,283	266	5,495	452	106	25,496	9,167	2,031	139	205	70	445	.245	.319	.406	.725
22	Rangers	310	362	.461	672	22,710	2,973	5,503	1,028	79	801	2,840	2,031	220	5,715	431	120	25,154	9,092	1,908	42	151	61	411	.242	.309	.400	.709
23	Angels	297	374	.443	671	22,467	2,811	5,334	989	97	810	2,685	1,965	290	6,093	370	136	24,936	8,947	1,896	76	138	98	450	.237	.305	.398	.703
24	Marlins	293	379	.436	672	22,594	2,618	5,471	1,021	91	637	2,491	1,796	249	5,900	461	131	24,878	8,585	1,749	87	152	74	502	.242	.303	.380	.683
25	Royals	291	381	.433	672	22,501	2,808	5,511	1,055	148	646	2,693	1,788	235	5,285	542	154	24,829	8,800	1,849	91	214	54	402	.245	.305	.391	.696