Since 2000, the New York Yankees have the most wins by a team, with 2,301 wins.

Interpreted as:

most MLB regular-season wins by team since 2000

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,301	1,668	.580	3,971	135,641	20,201	35,498	6,695	492	5,402	19,352	14,697	1,586	29,102	2,432	766	153,624	59,383	12,589	592	1,108	765	3,212	.262	.338	.438	.776
2	Dodgers	2,255	1,718	.568	3,973	134,902	18,381	34,722	6,817	685	4,438	17,535	13,640	1,494	28,907	2,322	854	152,361	56,223	11,940	1,266	1,059	1,064	2,958	.257	.330	.417	.747
3	Cardinals	2,189	1,781	.551	3,970	134,973	18,643	35,399	6,955	594	4,365	17,747	13,185	1,607	28,173	1,912	817	152,267	56,637	11,914	1,390	1,112	1,106	3,099	.262	.333	.420	.752
4	Braves	2,162	1,806	.545	3,969	135,425	18,451	35,143	7,030	602	4,504	17,623	13,253	1,299	29,877	1,970	780	152,324	56,889	12,136	1,349	998	1,051	3,068	.260	.329	.420	.749
5	Red Sox	2,159	1,815	.543	3,974	138,051	20,252	37,133	8,265	640	4,673	19,290	14,008	1,450	29,316	2,078	693	155,187	60,697	13,578	486	1,192	960	3,168	.269	.340	.440	.780
6	Giants	2,069	1,902	.521	3,972	135,159	17,412	34,522	6,957	846	3,863	16,574	12,789	1,280	28,444	1,785	754	151,656	54,760	11,666	1,307	1,121	1,236	3,100	.255	.323	.405	.728
7	Guardians	2,060	1,909	.519	3,969	135,363	18,603	35,009	7,279	629	4,314	17,724	13,269	1,557	28,768	2,400	864	152,165	56,488	12,222	818	1,158	763	3,013	.259	.329	.417	.747
8	Angels	2,046	1,926	.515	3,972	135,540	18,283	35,229	6,732	652	4,284	17,406	12,064	1,423	27,557	2,665	1,050	150,951	56,117	11,668	814	1,110	873	3,061	.260	.324	.414	.739
9	Athletics	2,042	1,929	.514	3,971	135,068	18,064	33,702	6,954	577	4,361	17,211	13,752	1,421	29,071	1,882	615	151,843	54,893	11,892	527	1,075	606	3,128	.250	.323	.406	.729
10	Astros	2,042	1,928	.514	3,971	135,048	18,300	34,842	6,977	622	4,567	17,458	12,824	1,509	28,865	2,282	908	151,590	56,764	12,166	1,140	1,069	818	3,157	.258	.327	.420	.747
11	Phillies	2,032	1,940	.512	3,972	135,706	18,231	34,532	6,945	791	4,420	17,386	13,474	1,487	30,423	2,556	685	152,843	56,319	12,156	1,196	980	1,129	2,756	.254	.326	.415	.741
12	Mets	1,994	1,977	.502	3,971	134,594	17,407	33,964	6,730	651	4,173	16,607	12,978	1,587	29,175	2,364	807	151,436	54,515	11,554	1,283	994	1,044	2,948	.252	.323	.405	.728
13	Twins	1,993	1,981	.502	3,974	136,256	18,360	35,440	7,186	764	4,093	17,416	12,702	1,374	28,881	2,077	857	152,123	56,433	12,043	690	1,101	750	3,101	.260	.327	.414	.741
14	Mariners	1,989	1,984	.501	3,973	135,426	17,444	34,243	6,474	577	4,137	16,599	12,535	1,473	29,812	2,533	921	151,237	54,282	11,188	769	1,034	763	2,856	.253	.321	.401	.721
15	Blue Jays	1,989	1,983	.501	3,972	135,967	18,758	35,085	7,370	574	4,845	17,915	12,751	1,428	28,596	1,923	715	151,766	58,138	12,789	552	1,068	583	3,179	.258	.326	.428	.753
16	Cubs	1,985	1,987	.500	3,973	135,078	17,900	34,276	6,918	713	4,466	17,043	13,013	1,565	31,045	2,001	831	151,946	56,018	12,097	1,323	967	947	2,938	.254	.324	.415	.739
17	Brewers	1,973	2,001	.496	3,975	134,313	17,712	33,707	6,795	671	4,584	16,919	13,097	1,648	32,212	2,661	898	151,238	55,596	12,050	1,227	953	919	2,999	.251	.323	.414	.737
18	Rays	1,970	2,001	.496	3,971	134,893	17,703	34,091	6,859	778	4,219	16,859	12,882	1,567	31,070	2,985	1,096	151,058	55,163	11,856	654	1,062	637	2,733	.253	.323	.409	.732
19	Rangers	1,951	2,023	.491	3,974	136,482	19,347	35,638	7,059	657	4,921	18,428	12,356	1,446	29,603	2,409	867	152,113	58,774	12,637	725	1,104	681	2,867	.261	.327	.431	.757
20	Diamondbacks	1,936	2,037	.487	3,973	135,461	18,067	34,432	7,143	968	4,205	17,225	13,211	1,300	30,155	2,276	819	152,298	56,126	12,316	1,217	1,109	1,004	2,847	.254	.324	.414	.738
21	White Sox	1,917	2,056	.483	3,973	135,237	17,929	34,768	6,565	559	4,611	17,181	11,528	1,512	29,111	2,204	979	150,154	56,284	11,735	869	1,008	547	3,085	.257	.320	.416	.736
22	Padres	1,905	2,069	.479	3,974	134,108	16,755	33,188	6,439	718	3,819	15,931	13,165	1,232	30,707	2,469	877	150,719	52,520	10,976	1,182	1,032	855	2,873	.247	.318	.392	.710
23	Nationals	1,889	2,082	.476	3,971	134,177	17,264	34,214	6,956	656	3,967	16,417	12,734	1,423	29,227	2,448	951	150,810	54,383	11,579	1,460	1,016	1,028	3,036	.255	.324	.405	.729
24	Reds	1,873	2,100	.471	3,975	134,720	17,722	33,890	6,717	597	4,555	16,921	13,076	1,691	31,357	2,512	950	151,842	55,466	11,869	1,390	965	929	2,821	.252	.323	.412	.735
25	Tigers	1,856	2,112	.468	3,968	136,039	17,697	35,430	6,791	944	4,076	16,933	11,664	1,216	29,724	1,804	820	150,735	56,337	11,811	738	1,078	672	3,075	.260	.322	.414	.736