Since 2000, the New York Yankees have the most wins by a team, with 2,286 wins.

Interpreted as:

most MLB regular-season wins by team since 2000

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,286	1,658	.580	3,946	134,803	20,064	35,282	6,655	488	5,361	19,220	14,597	1,572	28,861	2,410	760	152,664	58,996	12,504	592	1,100	761	3,195	.262	.338	.438	.776
2	Dodgers	2,239	1,709	.567	3,948	134,087	18,265	34,534	6,785	683	4,397	17,422	13,553	1,483	28,697	2,311	848	151,440	55,876	11,865	1,266	1,051	1,061	2,944	.258	.330	.417	.747
3	Cardinals	2,179	1,766	.552	3,945	134,094	18,523	35,167	6,904	593	4,342	17,633	13,097	1,599	27,971	1,891	813	151,284	56,283	11,839	1,387	1,107	1,098	3,078	.262	.333	.420	.752
4	Braves	2,152	1,792	.546	3,945	134,632	18,359	34,956	7,001	601	4,472	17,534	13,169	1,293	29,661	1,957	777	151,436	56,575	12,074	1,347	995	1,051	3,052	.260	.329	.420	.749
5	Red Sox	2,145	1,802	.543	3,947	137,127	20,128	36,908	8,213	637	4,645	19,171	13,905	1,440	29,059	2,048	688	154,144	60,330	13,495	486	1,186	952	3,154	.269	.340	.440	.780
6	Giants	2,052	1,893	.520	3,946	134,291	17,283	34,322	6,910	841	3,835	16,452	12,686	1,275	28,217	1,767	748	150,671	54,419	11,586	1,304	1,115	1,234	3,089	.256	.323	.405	.728
7	Guardians	2,046	1,899	.519	3,945	134,584	18,507	34,826	7,249	627	4,286	17,634	13,191	1,548	28,580	2,383	859	151,282	56,187	12,162	816	1,143	760	2,997	.259	.329	.417	.747
8	Angels	2,034	1,914	.515	3,948	134,748	18,188	35,059	6,701	649	4,248	17,312	12,011	1,411	27,330	2,656	1,048	150,086	55,802	11,598	813	1,103	869	3,046	.260	.325	.414	.739
9	Athletics	2,030	1,916	.514	3,946	134,212	17,955	33,485	6,914	573	4,326	17,107	13,677	1,420	28,891	1,874	611	150,906	54,523	11,813	526	1,071	606	3,106	.249	.323	.406	.729
10	Astros	2,029	1,917	.514	3,947	134,260	18,208	34,656	6,949	620	4,548	17,373	12,746	1,498	28,668	2,262	902	150,700	56,489	12,117	1,136	1,060	813	3,141	.258	.327	.421	.748
11	Phillies	2,019	1,928	.512	3,947	134,863	18,120	34,320	6,907	787	4,399	17,282	13,366	1,480	30,217	2,530	680	151,879	55,998	12,093	1,194	976	1,124	2,737	.254	.326	.415	.742
12	Twins	1,984	1,965	.502	3,949	135,443	18,275	35,264	7,143	761	4,074	17,336	12,630	1,356	28,674	2,061	853	151,216	56,151	11,978	690	1,097	749	3,087	.260	.327	.415	.742
13	Blue Jays	1,977	1,970	.501	3,947	135,135	18,670	34,884	7,325	573	4,832	17,832	12,671	1,416	28,415	1,905	710	150,827	57,851	12,730	547	1,058	581	3,160	.258	.326	.428	.754
14	Mets	1,976	1,970	.501	3,946	133,770	17,302	33,771	6,679	645	4,149	16,507	12,895	1,576	28,985	2,347	804	150,510	54,187	11,473	1,283	986	1,039	2,930	.252	.323	.405	.728
15	Mariners	1,975	1,973	.500	3,948	134,588	17,331	34,051	6,446	575	4,103	16,493	12,424	1,457	29,579	2,498	910	150,262	53,956	11,124	764	1,029	760	2,844	.253	.321	.401	.722
16	Cubs	1,969	1,977	.499	3,947	134,161	17,737	34,033	6,869	705	4,428	16,883	12,905	1,555	30,828	1,961	825	150,898	55,596	12,002	1,319	958	944	2,930	.254	.324	.414	.739
17	Brewers	1,960	1,988	.496	3,949	133,441	17,580	33,493	6,763	667	4,559	16,804	13,008	1,637	32,003	2,625	891	150,250	55,267	11,989	1,219	945	916	2,986	.251	.323	.414	.737
18	Rays	1,959	1,987	.496	3,946	134,060	17,594	33,879	6,815	775	4,196	16,754	12,802	1,562	30,864	2,956	1,091	150,133	54,832	11,786	654	1,055	637	2,708	.253	.323	.409	.732
19	Rangers	1,937	2,012	.491	3,949	135,688	19,267	35,462	7,026	655	4,891	18,350	12,300	1,438	29,409	2,388	861	151,250	58,471	12,572	725	1,099	679	2,850	.261	.327	.431	.758
20	Diamondbacks	1,922	2,026	.487	3,948	134,622	17,932	34,225	7,093	965	4,170	17,094	13,102	1,289	29,971	2,254	814	151,322	55,758	12,228	1,211	1,098	1,000	2,830	.254	.324	.414	.738
21	White Sox	1,911	2,037	.484	3,948	134,433	17,851	34,605	6,538	558	4,592	17,106	11,446	1,507	28,896	2,188	974	149,255	56,035	11,688	867	1,002	546	3,072	.257	.320	.417	.737
22	Padres	1,888	2,061	.478	3,949	133,288	16,652	32,972	6,400	717	3,795	15,837	13,081	1,227	30,538	2,444	872	149,797	52,191	10,912	1,175	1,026	851	2,858	.247	.318	.392	.710
23	Nationals	1,878	2,068	.476	3,946	133,364	17,159	34,025	6,922	653	3,940	16,318	12,658	1,417	29,043	2,422	943	149,904	54,073	11,515	1,455	1,010	1,028	3,024	.255	.324	.405	.729
24	Reds	1,861	2,087	.471	3,950	133,884	17,594	33,688	6,678	596	4,527	16,798	12,983	1,680	31,137	2,486	942	150,896	55,139	11,801	1,388	961	927	2,806	.252	.323	.412	.735
25	Tigers	1,841	2,102	.467	3,943	135,202	17,585	35,224	6,760	938	4,051	16,825	11,575	1,206	29,496	1,795	818	149,788	56,013	11,749	734	1,071	669	3,063	.261	.322	.414	.736