The New York Yankees have the highest run differential by a team, with a differential of 13,044 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,044	19,014	.569	10,778	8,148	648,050	92,367	172,057	28,550	5,487	17,241	85,817	68,399	4,904	94,421	11,617	2,790	734,213	263,304	51,278	9,594	3,266	2,822	10,654	.265	.339	.406	.745
2	Giants	7,434	21,723	.535	11,541	10,019	741,434	100,451	195,066	31,275	7,030	15,538	89,934	68,134	5,662	99,171	16,491	3,134	829,891	287,015	53,843	11,658	3,003	4,014	10,155	.263	.329	.387	.716
3	Dodgers	6,182	21,639	.532	11,432	10,068	737,318	97,644	192,639	30,976	6,997	14,055	87,875	68,722	5,133	99,956	17,309	3,541	827,064	279,774	52,028	12,771	3,044	3,726	9,908	.261	.327	.379	.707
4	Red Sox	3,577	19,301	.518	9,955	9,263	660,561	90,132	176,286	33,030	5,592	14,543	83,578	66,644	4,784	95,125	9,585	2,539	745,910	264,129	53,165	10,592	3,329	2,987	11,525	.267	.337	.400	.737
5	Cubs	3,521	22,255	.513	11,327	10,767	761,573	102,420	199,459	33,666	7,347	15,184	88,013	68,389	5,271	104,672	15,732	3,060	851,146	293,371	56,197	13,021	2,892	3,515	9,942	.262	.326	.385	.711
6	Guardians	2,263	19,312	.513	9,852	9,369	658,292	87,333	174,318	31,083	5,494	13,867	80,709	62,474	4,817	94,228	11,875	3,376	740,375	257,990	50,444	11,456	3,336	2,539	10,500	.265	.331	.392	.723
7	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
8	Cardinals	1,927	20,606	.513	10,505	9,970	704,855	92,184	187,320	31,738	7,048	12,815	84,258	64,028	5,179	97,788	14,983	3,605	789,157	271,599	51,601	11,968	3,127	3,767	10,098	.266	.330	.385	.715
9	Braves	1,525	22,217	.504	11,114	10,949	760,684	99,317	197,587	32,042	6,295	15,005	86,372	67,340	5,053	99,746	14,067	3,058	848,626	287,234	53,342	12,679	2,870	3,651	10,353	.260	.323	.378	.701
10	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
11	Grays	909	725	.612	438	278	26,572	4,037	6,764	1,084	341	98	292	1,192					27,764	8,824	1,523					.255		.332
12	Reds	736	21,839	.504	10,934	10,766	744,143	97,990	193,909	32,303	7,554	14,272	87,143	66,539	5,488	101,848	18,114	3,391	832,025	284,136	54,129	12,659	3,028	3,642	9,690	.261	.325	.382	.707
13	Astros	706	9,979	.502	5,009	4,965	338,686	42,566	86,347	15,839	2,167	8,381	40,058	32,205	2,880	62,556	7,125	3,123	380,495	131,663	26,387	4,022	2,702	3,139	7,372	.255	.323	.389	.711
14	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
15	Blue Jays	386	7,552	.498	3,761	3,788	258,775	34,939	67,314	13,450	1,490	8,216	33,138	23,990	2,407	48,625	4,544	1,954	288,773	108,392	23,156	1,491	2,110	1,393	5,893	.260	.326	.419	.745
16	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
17	Tigers	256	19,336	.503	9,676	9,567	659,394	88,770	174,227	29,517	6,288	14,520	81,735	65,386	4,426	96,301	11,272	2,933	743,305	259,880	50,325	11,005	3,094	2,443	10,686	.264	.333	.394	.727
18	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
19	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
20	Dark Blues	198	129	.619	78	48	5,022	770	1,348	159	53	6		69					5,091	1,631	218					.268		.325
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Brown Stockings	123	124	.589	73	51	4,656	670	1,173	124	63	3		116					4,772	1,432	190					.252		.308
24	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
25	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331