Casey Roussel has the most rushing yards in a game, with 36,526 yards against Memphis on October 30, 1999.

most rush yards by a player in a game

	NAME	RUSH YDS	DATE	TM		OPP	ATT	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	Casey Roussel C. Roussel	36,526	10/30/1999	TULN	vs	MEM	1	36526.0
2	Samaje Perine S. Perine	427	11/22/2014	OKLA	vs	KU	34	12.6	5	19	1	2	19.0	0
3	Jaret Patterson J. Patterson	409	11/28/2020	BUFF	vs	KENT	36	11.4	8
4	Melvin Gordon M. Gordon	408	11/15/2014	WIS	vs	NEB	25	16.3	4
5	LaDainian Tomlinson L. Tomlinson	406	11/20/1999	TCU	vs	UTEP	43	9.4		6	2		3.0
6	Darren Davis D. Davis	378	9/28/1996	ISU	vs	MIZ	41	9.2		-4	1		-4.0
7	Robbie Mixon R. Mixon	377	11/2/2002	CMU	@	EMU	43	8.8	4	7	1		7.0	0
8	Travis Prentice T. Prentice	376	11/6/1999	M-OH	vs	AKR	41	9.2		35	1		35.0
9	Astron Whatley A. Whatley	373	9/20/1997	KENT	@	EMU	42	8.9		0	2		0.0
10	Ka'Deem Carey K. Carey	366	11/10/2012	ARIZ	vs	COLO	25	14.6	5	34	2		17.0	0
11	Garrett Wolfe G. Wolfe	353	9/30/2006	NIU	@	BALL	31	11.4	3	3	3		1.0	0
12	Montel Harris M. Harris	351	11/17/2012	TEM	@	ARMY	36	9.8	7
13	Scott Harley S. Harley	351	11/30/1996	ECU	vs	NCST	42	8.4		5	2		2.5
14	Ricky Williams R. Williams	350	10/3/1998	TEX	vs	ISU	37	9.5		17	2		8.5
15	Shun White S. White	348	8/30/2008	NAVY	vs	TOWS	19	18.3	3
16	Leon Allen L. Allen	345	11/15/2014	WKU	vs	ARMY	33	10.5	3	12	2	3	6.0	0
17	Tavon Austin T. Austin	344	11/17/2012	WVU	vs	OKLA	21	16.4	2	82	4		20.5	0
18	Matt Forte M. Forte	342	10/20/2007	TULN	@	SMU	38	9.0	4
19	D'Onta Foreman D. Foreman	341	11/5/2016	TEX	@	TTU	33	10.3	3	0	0	1		0
20	Andre Williams A. Williams	339	11/16/2013	BC	vs	NCST	42	8.1	2
21	Ron Dayne R. Dayne	339	11/30/1996	WIS	@	HAW	36	9.4		8	1		8.0
22	Kasey Carrier K. Carrier	338	10/20/2012	UNM	@	AFA	39	8.7	3	5	1		5.0	0
23	Kay-Jay Harris K. Harris	337	9/4/2004	WVU	vs	ECU	25	13.5	4
24	Joe Williams J. Williams	332	10/22/2016	UTAH	@	UCLA	29	11.4	4
25	Trey Sermon T. Sermon	331	12/19/2020	OSU	vs	NW	29	11.4	2	4	3	6	1.3	0