16 players are tied for the most career hat tricks by an active defenseman, with 1 hat trick. The first three are Cale Makar, Jakob Chychrun and MacKenzie Weegar.

most regular-season hat tricks by a defenseman NHL active players

	NAME	HT	GP	G	A	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Cale Makar C. Makar	1	351	97	284	381	+115	102	35	128	2	3	23	5	986	9.8	0	0		320	470	263	242	24:38
2	Jakob Chychrun J. Chychrun	1	496	85	152	237	-58	332	30	37	0	0	12	3	1,179	7.2	0	0		591	773	172	389	21:15
3	MacKenzie Weegar M. Weegar	1	503	55	167	222	+100	363	6	27	1	7	9	1	966	5.7	1	1	100.0	1,082	885	310	489	20:36
4	Zach Werenski Z. Werenski	1	521	101	236	337	-5	134	25	81	1	2	14	6	1,412	7.2	0	0		293	676	251	317	23:37
5	Brandon Montour B. Montour	1	555	74	199	273	+40	407	14	71	3	1	17	3	1,236	6.0	0	0		631	605	169	372	21:13
6	Erik Gustafsson E. Gustafsson	1	481	45	182	227	-7	157	6	61	0	0	6	2	751	6.0	0	1	0.0	435	481	149	360	18:42
7	Jaccob Slavin J. Slavin	1	699	50	232	282	+156	88	7	21	4	11	7	3	1,214	4.1	0	1	0.0	423	1,159	672	404	22:29
8	Hampus Lindholm H. Lindholm	1	761	73	239	312	+147	441	14	67	1	4	13	3	1,294	5.6	2	8	25.0	698	976	270	646	22:22
9	Rasmus Ristolainen R. Ristolainen	1	748	53	240	293	-186	373	15	102	1	4	7	4	1,398	3.8	1	2	50.0	1,861	1,214	179	406	22:43
10	Nikita Zadorov N. Zadorov	1	678	49	106	155	+18	758	2	7	0	1	5	1	817	6.0	1	1	100.0	1,867	702	193	430	18:11
11	Dougie Hamilton D. Hamilton	1	808	147	337	484	+71	514	46	114	1	2	32	9	2,318	6.3	1	4	25.0	937	890	249	644	20:39
12	Justin Faulk J. Faulk	1	936	127	308	435	-64	460	46	92	3	5	32	4	2,222	5.7	0	1	0.0	1,537	1,266	561	611	23:04
13	Cam Fowler C. Fowler	1	997	96	363	459	-125	263	38	136	4	5	18	4	1,570	6.1	2	3	66.7	476	1,376	336	610	23:12
14	Jared Spurgeon J. Spurgeon	1	896	114	282	396	+121	156	33	93	0	6	22	5	1,492	7.6	1	3	33.3	762	1,537	254	282	22:12
15	Erik Karlsson E. Karlsson	1	1,038	192	649	841	-103	478	43	255	2	5	37	11	2,868	6.7	0	4	0.0	763	1,378	825	1,202	25:18
16	Ryan Suter R. Suter	1	1,480	106	582	688	+116	775	36	218	4	12	20	2	2,392	4.4	2	5	40.0	1,185	1,982	539	725	24:17