Bruce Smith has the most career sacks by a defensive lineman, with 200 sacks.

most defensive sacks by an inside defensive tackle in NFL history

	NAME	SCK	GP	TKL	AST	COMB	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Bruce Smith B. Smith	200.0	279	85	28	113		2	0	0	6	15	1
2	Reggie White R. White	198.0	232					3	79	0		20	2
3	Chris Doleman C. Doleman	147.0	200					6	57	1		21	1
4	Michael Strahan M. Strahan	141.5	216	338	93	431		4	124	2	14	15	1
5	John Randle J. Randle	137.5	219	51	15	66		1	1	0	4	11	1
6	Richard Dent R. Dent	137.5	203					8	89	1		13	1
7	Jared Allen J. Allen	136.0	187	503	145	648	851.5	6	55	1	31	19	1
8	Julius Peppers J. Peppers	134.5	218	487	127	614	813.5	9	192	2	43	17	2
9	Simeon Rice S. Rice	122.0	174	214	38	252		5	48	0	25	8	0
10	Clyde Simmons C. Simmons	121.5	236					3	85	2		14	2
11	Jason Taylor J. Taylor	120.5	185	336	152	488		7	110	3	34	26	5
12	Cameron Jordan C. Jordan	117.5	209	444	238	682	779.5	2	6	1	15	11	0
13	John Abraham J. Abraham	117.5	169	414	87	501	748.5	1	6	0	42	6	1
14	J.J. Watt	114.5	151	449	137	586	808.5	2	99	2	27	17	1
15	Sean Jones S. Jones	113.0	201					1	0	0		13	1
16	Aaron Donald A. Donald	111.0	154	340	203	543	813	0	0	0	24	7	0
17	Dwight Freeney D. Freeney	108.5	173	267	41	308	813	0	0	0	43	3	1
18	Trace Armstrong T. Armstrong	106.0	211	31	9	40		1	0	0	1	15	0
19	Calais Campbell C. Campbell	105.5	244	616	249	865	723	3	24	0	17	13	3
20	Kevin Carter K. Carter	104.5	224	233	133	366		0	0	0	5	14	0
21	Neil Smith N. Smith	104.5	191					4	68	1		12	1
22	Robert Mathis R. Mathis	103.0	151	349	108	457	723.5	0	0	0	47	14	1
23	Jim Jeffcoat J. Jeffcoat	102.5	227					2	91	2		11	2
24	William Fuller W. Fuller	100.5	194					2	9	0		8	1
25	Greg Townsend G. Townsend	99.0	174					3	117	1		7	3