Jamie Morris has the most rush attempts in a game, with 45 carries against the Bengals on December 17, 1988.

most runs by a player scored in a regular-season game

	NAME	ATT	DATE	TM		OPP	RUSH YDS	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	Jamie Morris J. Morris	45	12/17/1988	WAS	@	CIN	152	3.4	0	0	0			0
2	Rudi Johnson R. Johnson	43	11/9/2003	CIN	vs	HOU	182	4.2	2	18	2	2	9.0	0
3	James Wilder J. Wilder	43	9/30/1984	TB	vs	GB	172	4.0	1	44	4		11.0	0
4	Butch Woolfolk B. Woolfolk	43	11/20/1983	NYG	@	PHI	159	3.7	1	0	0			0
5	Ricky Williams R. Williams	42	9/21/2003	MIA	vs	BUF	153	3.6	1	-4	3	4	-1.3	0
6	Terrell Davis T. Davis	42	10/26/1997	DEN	@	BUF	207	4.9	1	29	5		5.8	0
7	James Wilder J. Wilder	42	10/30/1983	TB	@	PIT	126	3.0	0	48	6		8.0	0
8	Rodney Hampton R. Hampton	41	9/19/1993	NYG	vs	RAM	134	3.3	1	40	3		13.3	0
9	Gerald Riggs G. Riggs	41	11/17/1985	ATL	vs	RAM	123	3.0	3	16	5		3.2	0
10	Franco Harris F. Harris	41	10/17/1976	PIT	vs	CIN	143	3.5	2	0	0			0
11	Shaun Alexander S. Alexander	40	11/27/2006	SEA	vs	GB	201	5.0	0	0	0	1		0
12	Ricky Williams R. Williams	40	10/31/1999	NO	vs	CLE	179	4.5	0	8	3	3	2.7	0
13	Adrian Murrell A. Murrell	40	9/28/1997	NYJ	@	CIN	156	3.9	1	4	1		4.0	0
14	Curtis Martin C. Martin	40	9/14/1997	NE	vs	NYJ	199	5.0	1	15	2		7.5	0
15	Errict Rhett E. Rhett	40	12/4/1994	TB	vs	WAS	192	4.8	1	0	0			0
16	Barry Sanders B. Sanders	40	9/19/1994	DET	@	DAL	194	4.9	0	0	0			0
17	Johnny Hector J. Hector	40	10/12/1986	NYJ	@	NE	143	3.6	3	8	2		4.0	0
18	Walter Payton W. Payton	40	11/20/1977	CHI	vs	MIN	275	6.9	1	6	1		6.0	0
19	Lydell Mitchell L. Mitchell	40	10/20/1974	BAL	@	NYJ	156	3.9	1	6	2		3.0	0
20	Jerome Harrison J. Harrison	39	12/27/2009	CLE	vs	OAK	148	3.8	1	0	0	0		0
21	Larry Johnson L. Johnson	39	10/29/2006	KC	vs	SEA	155	4.0	3	26	2	5	13.0	1
22	LaDainian Tomlinson L. Tomlinson	39	10/20/2002	SD	@	OAK	153	3.9	1	28	5	6	5.6	1
23	Corey Dillon C. Dillon	39	12/4/1997	CIN	vs	TEN	246	6.3	4	30	2		15.0	0
24	Jerome Bettis J. Bettis	39	1/2/1994	RAM	vs	CHI	146	3.7	1	71	5		14.2	0
25	Earnest Byner E. Byner	39	12/15/1990	WAS	@	NE	149	3.8	1	0	0			0