Matthew Stafford has a passer rating of 89.1 with 5,652 yards, 36 touchdowns and 15 interceptions in 23 games against the Vikings in his career.
| NAME | DATE | TM | OPP | CMP | ATT | PCT | YDS | AVG | TD | INT | RTG | TD% | INT% | SCK | SCKY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | M. Stafford | 9/20/2009 |  DET | vs |  MIN | 18 | 30 | 60.0 | 152 | 5.1 | 1 | 2 | 56.5 | 3.3 | 6.7 | 2 | 16 |
| 2 | | M. Stafford | 11/15/2009 | DET | @ | MIN | 29 | 51 | 56.9 | 224 | 4.4 | 1 | 0 | 74.3 | 2.0 | 0.0 | 3 | 20 |
| 3 | | M. Stafford | 9/25/2011 | DET | @ | MIN | 32 | 46 | 69.6 | 378 | 8.2 | 2 | 0 | 108.8 | 4.3 | 0.0 | 5 | 40 |
| 4 | | M. Stafford | 12/11/2011 | DET | vs | MIN | 20 | 29 | 69.0 | 227 | 7.8 | 2 | 0 | 115.2 | 6.9 | 0.0 | 5 | 19 |
| 5 | | M. Stafford | 9/30/2012 | DET | vs | MIN | 30 | 51 | 58.8 | 319 | 6.3 | 0 | 0 | 77.2 | 0.0 | 0.0 | 5 | 33 |
| 6 | | M. Stafford | 11/11/2012 | DET | @ | MIN | 28 | 42 | 66.7 | 329 | 7.8 | 3 | 1 | 104.2 | 7.1 | 2.4 | 2 | 21 |
| 7 | | M. Stafford | 9/8/2013 | DET | vs | MIN | 28 | 43 | 65.1 | 357 | 8.3 | 2 | 1 | 96.8 | 4.7 | 2.3 | 0 | 0 |
| 8 | | M. Stafford | 12/29/2013 | DET | @ | MIN | 22 | 33 | 66.7 | 217 | 6.6 | 1 | 0 | 95.1 | 3.0 | 0.0 | 5 | 35 |
| 9 | | M. Stafford | 10/12/2014 | DET | @ | MIN | 19 | 33 | 57.6 | 185 | 5.6 | 1 | 0 | 83.5 | 3.0 | 0.0 | 4 | 30 |
| 10 | | M. Stafford | 12/14/2014 | DET | vs | MIN | 17 | 28 | 60.7 | 153 | 5.5 | 1 | 0 | 87.4 | 3.6 | 0.0 | 0 | 0 |
| 11 | | M. Stafford | 9/20/2015 | DET | @ | MIN | 32 | 53 | 60.4 | 286 | 5.4 | 2 | 1 | 79.6 | 3.8 | 1.9 | 1 | 1 |
| 12 | | M. Stafford | 10/25/2015 | DET | vs | MIN | 18 | 26 | 69.2 | 256 | 9.8 | 2 | 0 | 126.4 | 7.7 | 0.0 | 7 | 59 |
| 13 | | M. Stafford | 11/6/2016 | DET | @ | MIN | 23 | 36 | 63.9 | 219 | 6.1 | 2 | 1 | 87.6 | 5.6 | 2.8 | 1 | 5 |
| 14 | | M. Stafford | 11/24/2016 | DET | vs | MIN | 23 | 40 | 57.5 | 232 | 5.8 | 1 | 0 | 82.5 | 2.5 | 0.0 | 2 | 18 |
| 15 | | M. Stafford | 10/1/2017 | DET | @ | MIN | 19 | 31 | 61.3 | 209 | 6.7 | 0 | 0 | 81.3 | 0.0 | 0.0 | 6 | 55 |
| 16 | | M. Stafford | 11/23/2017 | DET | vs | MIN | 20 | 35 | 57.1 | 250 | 7.1 | 2 | 1 | 86.6 | 5.7 | 2.9 | 3 | 14 |
| 17 | | M. Stafford | 11/4/2018 | DET | @ | MIN | 25 | 36 | 69.4 | 199 | 5.5 | 0 | 0 | 83.0 | 0.0 | 0.0 | 10 | 56 |
| 18 | | M. Stafford | 12/23/2018 | DET | vs | MIN | 18 | 32 | 56.3 | 116 | 3.6 | 0 | 0 | 64.1 | 0.0 | 0.0 | 2 | 11 |
| 19 | | M. Stafford | 10/20/2019 | DET | vs | MIN | 30 | 45 | 66.7 | 364 | 8.1 | 4 | 1 | 111.7 | 8.9 | 2.2 | 2 | 12 |
| 20 | | M. Stafford | 11/8/2020 | DET | @ | MIN | 23 | 32 | 71.9 | 211 | 6.6 | 1 | 2 | 73.8 | 3.1 | 6.3 | 2 | 13 |
| 21 | | M. Stafford | 1/3/2021 | DET | vs | MIN | 20 | 31 | 64.5 | 293 | 9.5 | 3 | 1 | 114.0 | 9.7 | 3.2 | 1 | 5 |
| 22 |  | M. Stafford | 12/26/2021 |  LAR | @ | MIN | 21 | 37 | 56.8 | 197 | 5.3 | 1 | 3 | 46.8 | 2.7 | 8.1 | 0 | 0 |
| 23 | | M. Stafford | 10/24/2024 | LAR | vs | MIN | 25 | 34 | 73.5 | 279 | 8.2 | 4 | 1 | 124.5 | 11.8 | 2.9 | 0 | 0 |
| Average | 23.5 | 37.1 | 63.2 | 245.7 | 6.6 | 1.6 | 0.7 | 89.1 | 4.2 | 1.8 | 3.0 | 20.1 | ||||||
| Total | 540 | 854 | 63.2 | 5,652 | 6.6 | 36 | 15 | 89.1 | 4.2 | 1.8 | 68 | 463 |
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
| Lions | 15 | 2 | 0 | .882 |
| Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
 Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
| Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
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