Matthew Stafford has a record of 4-8 in the regular-season and playoffs against the 49ers in his career.
| NAME | DATE | REC | TM | OPP | W% | CMP | ATT | PCT | YDS | AVG | TD | INT | RTG | TD% | INT% | SCK | SCKY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | M. Stafford | 10/16/2011 | 0-1 |  DET | vs |  SF | .000 | 28 | 50 | 56.0 | 293 | 5.9 | 2 | 0 | 86.5 | 4.0 | 0.0 | 5 | 49 |
| 2 | | M. Stafford | 9/16/2012 | 0-1 | DET | @ | SF | .000 | 19 | 32 | 59.4 | 230 | 7.2 | 1 | 1 | 78.9 | 3.1 | 3.1 | 2 | 16 |
| 3 | | M. Stafford | 12/27/2015 | 1-0 | DET | vs | SF | 1.000 | 29 | 37 | 78.4 | 301 | 8.1 | 2 | 0 | 118.6 | 5.4 | 0.0 | 2 | 17 |
| 4 | | M. Stafford | 9/16/2018 | 0-1 | DET | @ | SF | .000 | 34 | 53 | 64.2 | 347 | 6.5 | 3 | 0 | 101.7 | 5.7 | 0.0 | 2 | 18 |
| 5 |  | M. Stafford | 11/15/2021 | 0-1 |  LAR | @ | SF | .000 | 26 | 41 | 63.4 | 243 | 5.9 | 1 | 2 | 67.4 | 2.4 | 4.9 | 2 | 19 |
| 6 | | M. Stafford | 1/9/2022 | 0-1 | LAR | vs | SF | .000 | 21 | 32 | 65.6 | 238 | 7.4 | 3 | 2 | 93.0 | 9.4 | 6.3 | 5 | 37 |
| 7 | | M. Stafford | 1/30/2022 | 1-0 | LAR | vs | SF | 1.000 | 31 | 45 | 68.9 | 337 | 7.5 | 2 | 1 | 96.3 | 4.4 | 2.2 | 2 | 11 |
| 8 | | M. Stafford | 10/3/2022 | 0-1 | LAR | @ | SF | .000 | 32 | 48 | 66.7 | 254 | 5.3 | 0 | 1 | 71.0 | 0.0 | 2.1 | 7 | 54 |
| 9 | | M. Stafford | 10/30/2022 | 0-1 | LAR | vs | SF | .000 | 22 | 33 | 66.7 | 187 | 5.7 | 1 | 0 | 91.4 | 3.0 | 0.0 | 2 | 20 |
| 10 | | M. Stafford | 9/17/2023 | 0-1 | LAR | vs | SF | .000 | 34 | 55 | 61.8 | 307 | 5.6 | 1 | 2 | 67.8 | 1.8 | 3.6 | 1 | 10 |
| 11 | | M. Stafford | 9/22/2024 | 1-0 | LAR | vs | SF | 1.000 | 16 | 25 | 64.0 | 221 | 8.8 | 1 | 0 | 105.6 | 4.0 | 0.0 | 3 | 23 |
| 12 | | M. Stafford | 12/12/2024 | 1-0 | LAR | @ | SF | 1.000 | 16 | 27 | 59.3 | 160 | 5.9 | 0 | 0 | 76.2 | 0.0 | 0.0 | 0 | 0 |
| Average | .333 | 25.7 | 39.8 | 64.4 | 259.8 | 6.5 | 1.4 | 0.8 | 87.0 | 3.6 | 1.9 | 2.8 | 22.8 | |||||||
| Total | 4-8 | .333 | 308 | 478 | 64.4 | 3,118 | 6.5 | 17 | 9 | 87.0 | 3.6 | 1.9 | 33 | 274 |
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Bills 
Dolphins 
Steelers 
Ravens 
Texans 
Colts 
Chiefs 
Chargers | NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 12 | 3 | 0 | .800 |
 Commanders | 10 | 5 | 0 | .667 |
| NFC North | W | L | T | PCT |
| Lions | 13 | 2 | 0 | .867 |
 Vikings | 13 | 2 | 0 | .867 |
| NFC South | W | L | T | PCT |
 Falcons | 8 | 7 | 0 | .533 |
 Buccaneers | 8 | 7 | 0 | .533 |
| NFC West | W | L | T | PCT |
| Rams | 9 | 6 | 0 | .600 |
 Seahawks | 8 | 7 | 0 | .533 |
DAL 
JAX 
LV 
NE 
NYJ 
TEN 
ARI 
