Matthew Stafford has a passer rating of 92.2 with 3,619 yards, 22 touchdowns and 10 interceptions in 15 games against the Cardinals in his career.
| NAME | DATE | TM | OPP | CMP | ATT | PCT | YDS | AVG | TD | INT | RTG | TD% | INT% | SCK | SCKY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | M. Stafford | 12/16/2012 |  DET | @ |  ARI | 24 | 50 | 48.0 | 246 | 4.9 | 0 | 3 | 37.6 | 0.0 | 6.0 | 2 | 18 |
| 2 | | M. Stafford | 9/15/2013 | DET | @ | ARI | 24 | 36 | 66.7 | 278 | 7.7 | 2 | 0 | 108.3 | 5.6 | 0.0 | 1 | 5 |
| 3 | | M. Stafford | 11/16/2014 | DET | @ | ARI | 18 | 30 | 60.0 | 183 | 6.1 | 0 | 1 | 63.6 | 0.0 | 3.3 | 4 | 19 |
| 4 | | M. Stafford | 10/11/2015 | DET | vs | ARI | 20 | 32 | 62.5 | 188 | 5.9 | 1 | 3 | 50.0 | 3.1 | 9.4 | 1 | 0 |
| 5 | | M. Stafford | 9/10/2017 | DET | vs | ARI | 29 | 41 | 70.7 | 292 | 7.1 | 4 | 1 | 113.1 | 9.8 | 2.4 | 1 | 7 |
| 6 | | M. Stafford | 12/9/2018 | DET | @ | ARI | 15 | 23 | 65.2 | 101 | 4.4 | 0 | 0 | 74.7 | 0.0 | 0.0 | 1 | 5 |
| 7 | | M. Stafford | 9/8/2019 | DET | @ | ARI | 27 | 45 | 60.0 | 385 | 8.6 | 3 | 0 | 110.0 | 6.7 | 0.0 | 3 | 24 |
| 8 | | M. Stafford | 9/27/2020 | DET | @ | ARI | 22 | 31 | 71.0 | 270 | 8.7 | 2 | 0 | 119.0 | 6.5 | 0.0 | 4 | 38 |
| 9 |  | M. Stafford | 10/3/2021 |  LAR | vs | ARI | 26 | 41 | 63.4 | 280 | 6.8 | 2 | 1 | 89.5 | 4.9 | 2.4 | 0 | 0 |
| 10 | | M. Stafford | 12/13/2021 | LAR | @ | ARI | 23 | 30 | 76.7 | 287 | 9.6 | 3 | 0 | 139.2 | 10.0 | 0.0 | 3 | 20 |
| 11 | | M. Stafford | 9/25/2022 | LAR | @ | ARI | 18 | 25 | 72.0 | 249 | 10.0 | 0 | 0 | 103.6 | 0.0 | 0.0 | 1 | 10 |
| 12 | | M. Stafford | 10/15/2023 | LAR | vs | ARI | 15 | 24 | 62.5 | 226 | 9.4 | 1 | 0 | 107.3 | 4.2 | 0.0 | 3 | 23 |
| 13 | | M. Stafford | 11/26/2023 | LAR | @ | ARI | 25 | 33 | 75.8 | 229 | 6.9 | 4 | 1 | 121.1 | 12.1 | 3.0 | 0 | 0 |
| 14 | | M. Stafford | 9/15/2024 | LAR | @ | ARI | 19 | 27 | 70.4 | 216 | 8.0 | 0 | 0 | 94.1 | 0.0 | 0.0 | 5 | 24 |
| 15 | | M. Stafford | 12/28/2024 | LAR | vs | ARI | 17 | 32 | 53.1 | 189 | 5.9 | 0 | 0 | 71.0 | 0.0 | 0.0 | 0 | 0 |
| Average | 21.5 | 33.3 | 64.4 | 241.3 | 7.2 | 1.5 | 0.7 | 92.2 | 4.4 | 2.0 | 1.9 | 12.9 | ||||||
| Total | 322 | 500 | 64.4 | 3,619 | 7.2 | 22 | 10 | 92.2 | 4.4 | 2.0 | 29 | 193 |
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
| Lions | 15 | 2 | 0 | .882 |
 Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
 Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
| Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
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