The Green Bay Packers had the fewest penalties by a team in 2021, with 69 penalties.

	TEAM	PEN	SEASON	GP	W	L	T	TD	PTS	PPG	OPP PTS	OPP PPG	1DWN	3DWN%	4DWN%
1	Packers	69	2021	17	13	4	0	54	450	26.5	371	21.8	375	43.6	59.1
2	Bengals	72	2021	17	10	7	0	54	460	27.1	376	22.1	337	39.6	65.0
3	Rams	76	2021	17	12	5	0	52	460	27.1	372	21.9	355	43.9	52.6
4	Colts	76	2021	17	9	8	0	52	451	26.5	365	21.5	354	41.0	62.1
5	Washington Football Team	82	2021	17	7	10	0	37	335	19.7	434	25.5	345	38.8	50.0
6	Broncos	83	2021	17	7	10	0	37	335	19.7	322	18.9	331	38.5	57.1
7	Giants	88	2021	17	4	13	0	24	258	15.2	416	24.5	299	36.5	43.3
8	Falcons	92	2021	17	7	10	0	33	313	18.4	459	27.0	306	38.9	41.7
9	Patriots	95	2021	17	10	7	0	51	462	27.2	303	17.8	362	43.5	64.7
10	Seahawks	97	2021	17	7	10	0	49	395	23.2	366	21.5	302	37.3	36.4
11	Buccaneers	97	2021	17	13	4	0	63	511	30.1	353	20.8	404	47.1	56.3
12	Saints	98	2021	17	9	8	0	43	364	21.4	335	19.7	307	35.5	52.4
13	49ers	102	2021	17	10	7	0	50	427	25.1	365	21.5	361	40.2	50.0
14	Ravens	102	2021	17	8	9	0	41	387	22.8	392	23.1	394	36.4	66.7
15	Jets	103	2021	17	4	13	0	36	310	18.2	504	29.6	310	36.3	48.3
16	Titans	103	2021	17	12	5	0	49	419	24.6	354	20.8	362	43.6	62.5
17	Jaguars	104	2021	17	3	14	0	28	253	14.9	457	26.9	304	35.8	58.1
18	Lions	105	2021	17	3	13	1	35	325	19.1	467	27.5	329	34.7	51.2
19	Dolphins	105	2021	17	9	8	0	39	341	20.1	373	21.9	325	40.8	54.5
20	Bears	106	2021	17	6	11	0	33	311	18.3	407	23.9	333	34.7	41.7
21	Eagles	107	2021	17	9	8	0	50	444	26.1	385	22.6	352	45.7	45.8
22	Steelers	107	2021	17	9	7	1	34	343	20.2	398	23.4	323	38.9	47.6
23	Panthers	107	2021	17	5	12	0	32	304	17.9	404	23.8	322	35.7	41.2
24	Chiefs	111	2021	17	12	5	0	57	480	28.2	364	21.4	419	52.2	66.7
25	Vikings	111	2021	17	8	9	0	48	425	25.0	426	25.1	332	36.4	54.5