DeAndre Hopkins has had 120 catches for 1,456 yards and has scored 12 touchdowns in 23 games against the AFC West in his career.
| NAME | DATE | TM | OPP | REC | TRG | REC YDS | AVG | REC TD | RUSH YDS | ATT | YPC | RUSH TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Hopkins | 9/9/2013 |  HOU | @ |  SD | 5 | 6 | 66 | 13.2 | 0 | 0 | 0 | 0 | |
| 2 | | D. Hopkins | 10/20/2013 | HOU | @ |  KC | 3 | 4 | 76 | 25.3 | 1 | 0 | 0 | 0 | |
| 3 | | D. Hopkins | 11/17/2013 | HOU | vs |  OAK | 1 | 2 | 7 | 7.0 | 0 | 0 | 0 | 0 | |
| 4 | | D. Hopkins | 12/22/2013 | HOU | vs |  DEN | 1 | 4 | 8 | 8.0 | 0 | 0 | 0 | 0 | |
| 5 | | D. Hopkins | 9/14/2014 | HOU | @ | OAK | 3 | 5 | 22 | 7.3 | 1 | 0 | 0 | 0 | |
| 6 | | D. Hopkins | 9/13/2015 | HOU | vs | KC | 9 | 13 | 98 | 10.9 | 2 | 0 | 0 | 0 | |
| 7 | | D. Hopkins | 9/18/2016 | HOU | vs | KC | 7 | 11 | 113 | 16.1 | 1 | 0 | 0 | 0 | |
| 8 | | D. Hopkins | 10/24/2016 | HOU | @ | DEN | 5 | 12 | 36 | 7.2 | 0 | 0 | 0 | 0 | |
| 9 | | D. Hopkins | 11/21/2016 | HOU | @ | OAK | 5 | 6 | 58 | 11.6 | 0 | 0 | 0 | 0 | |
| 10 | | D. Hopkins | 11/27/2016 | HOU | vs | SD | 5 | 10 | 70 | 14.0 | 0 | 0 | 0 | 0 | |
| 11 | | D. Hopkins | 10/8/2017 | HOU | vs | KC | 4 | 12 | 52 | 13.0 | 3 | 0 | 0 | 0 | |
| 12 | | D. Hopkins | 11/4/2018 | HOU | @ | DEN | 10 | 12 | 105 | 10.5 | 1 | 0 | 0 | 0 | |
| 13 | | D. Hopkins | 9/22/2019 | HOU | @ | LAC | 6 | 7 | 67 | 11.2 | 0 | 0 | 0 | 0 | |
| 14 | | D. Hopkins | 10/13/2019 | HOU | @ | KC | 9 | 12 | 55 | 6.1 | 0 | 0 | 0 | 0 | |
| 15 | | D. Hopkins | 10/27/2019 | HOU | vs | OAK | 11 | 13 | 109 | 9.9 | 0 | 0 | 0 | 0 | |
| 16 | | D. Hopkins | 12/8/2019 | HOU | vs | DEN | 7 | 13 | 120 | 17.1 | 1 | 12 | 1 | 12.0 | 0 |
| 17 |  | D. Hopkins | 11/27/2022 |  ARI | vs | LAC | 4 | 6 | 87 | 21.8 | 1 | 0 | 0 | 0 | |
| 18 | | D. Hopkins | 12/18/2022 | ARI | @ | DEN | 7 | 11 | 60 | 8.6 | 0 | 0 | 0 | 0 | |
| 19 |  | D. Hopkins | 9/17/2023 |  TEN | vs | LAC | 4 | 5 | 40 | 10.0 | 0 | 0 | 0 | 0 | |
| 20 |  | D. Hopkins | 10/27/2024 | KC | @ | LV | 2 | 3 | 29 | 14.5 | 0 | 0 | 0 | 0 | |
| 21 | | D. Hopkins | 11/10/2024 | KC | vs | DEN | 4 | 5 | 56 | 14.0 | 0 | 0 | 0 | 0 | |
| 22 | | D. Hopkins | 11/29/2024 | KC | vs | LV | 4 | 9 | 90 | 22.5 | 0 | 0 | 0 | 0 | |
| 23 | | D. Hopkins | 12/8/2024 | KC | vs | LAC | 4 | 9 | 32 | 8.0 | 1 | 0 | 0 | 0 | |
| Average | 5.2 | 8.3 | 63.3 | 12.1 | 0.5 | 0.5 | 0.0 | 12.0 | 0.0 | ||||||
| Total | 120 | 190 | 1,456 | 12.1 | 12 | 12 | 1 | 12.0 | 0 |
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
 Lions | 15 | 2 | 0 | .882 |
 Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
 Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
 Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
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