O.J. Simpson has the most rushing yards for the Bills in a game, with 273 yards against the Lions on November 25, 1976.
Interpreted as:
bills single regular-season game rushing leaders record| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 273 | 11/25/1976 |  BUF | @ |  DET | 29 | 9.4 | 2 | 0 | 0 | 0 | ||
| 2 | | O.J. Simpson | 250 | 9/16/1973 | BUF | @ |  NE | 29 | 8.6 | 2 | 0 | 0 | 0 | ||
| 3 |  | C. Gilchrist | 243 | 12/8/1963 | BUF | vs |  NYJ | 36 | 6.8 | 5 | 0 | 0 | 0 | ||
| 4 | | O.J. Simpson | 227 | 9/28/1975 | BUF | @ |  PIT | 28 | 8.1 | 1 | 0 | 0 | 0 | ||
| 5 | | O.J. Simpson | 219 | 12/9/1973 | BUF | vs | NE | 22 | 10.0 | 1 | 0 | 0 | 0 | ||
| 6 | | T. Thomas | 214 | 9/24/1990 | BUF | @ | NYJ | 18 | 11.9 | 0 | 5 | 3 | 1.7 | 0 | |
| 7 | | F. Jackson | 212 | 1/3/2010 | BUF | vs |  IND | 33 | 6.4 | 0 | 15 | 2 | 2 | 7.5 | 1 |
| 8 | | T. Miller | 208 | 11/26/1978 | BUF | vs |  NYG | 21 | 9.9 | 2 | 7 | 2 | 3.5 | 0 | |
| 9 | | G. Bell | 206 | 11/18/1984 | BUF | vs |  DAL | 27 | 7.6 | 1 | 12 | 2 | 6.0 | 1 | |
| 10 | | O.J. Simpson | 203 | 12/5/1976 | BUF | @ |  MIA | 24 | 8.5 | 1 | 12 | 2 | 6.0 | 0 | |
| 11 | | O.J. Simpson | 200 | 12/16/1973 | BUF | @ | NYJ | 34 | 5.9 | 1 | 0 | 0 | 0 | ||
| 12 | | O.J. Simpson | 197 | 11/17/1975 | BUF | @ |  CIN | 17 | 11.6 | 2 | 21 | 2 | 10.5 | 0 | |
| 13 | | O.J. Simpson | 189 | 10/29/1972 | BUF | vs | PIT | 22 | 8.6 | 1 | 7 | 3 | 2.3 | 0 | |
| 14 | | J. Cribbs | 185 | 12/4/1983 | BUF | @ |  KC | 36 | 5.1 | 0 | 0 | 0 | 0 | ||
| 15 | | O.J. Simpson | 185 | 12/14/1975 | BUF | @ | NE | 21 | 8.8 | 1 | 28 | 2 | 14.0 | 0 | |
| 16 | | K. Davis | 181 | 11/22/1992 | BUF | vs |  ATL | 20 | 9.1 | 2 | 4 | 1 | 4.0 | 0 | |
| 17 |  | J. Cook | 179 | 12/17/2023 | BUF | vs | DAL | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 |
| 18 | | O.J. Simpson | 173 | 9/21/1975 | BUF | vs | NYJ | 32 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |
| 19 | | O.J. Simpson | 171 | 12/12/1976 | BUF | @ |  BAL | 28 | 6.1 | 1 | 18 | 1 | 18.0 | 0 | |
| 20 | | O.J. Simpson | 171 | 10/7/1973 | BUF | vs |  PHI | 27 | 6.3 | 1 | 33 | 3 | 11.0 | 0 | |
| 21 | | C.J. Spiller | 169 | 9/9/2012 | BUF | @ |  NYJ | 14 | 12.1 | 1 | 25 | 2 | 3 | 12.5 | 0 |
| 22 | | T. Henry | 169 | 12/7/2003 | BUF | vs | NYJ | 32 | 5.3 | 1 | 6 | 1 | 1 | 6.0 | 0 |
| 23 | | T. Henry | 167 | 10/19/2003 | BUF | vs |  WAS | 31 | 5.4 | 2 | 13 | 1 | 2 | 13.0 | 0 |
| 24 | | J. Cribbs | 166 | 9/25/1983 | BUF | vs |  HOU | 22 | 7.5 | 1 | 0 | 0 | 0 | ||
| 25 | | O.J. Simpson | 166 | 10/31/1976 | BUF | vs | NYJ | 29 | 5.7 | 0 | 0 | 0 | 0 | ||
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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