The San Francisco 49ers had the highest point differential by a team in 2022, with a 173-point differential.

	TEAM	DIFF	SEASON	GP	W	L	T	TD	PTS	PPG	OPP PTS	OPP PPG	1DWN	3DWN%	4DWN%
1	49ers	173	2022	17	13	4	0	53	450	26.5	277	16.3	347	45.0	41.2
2	Bills	169	2022	16	13	3	0	53	455	28.4	286	17.9	367	50.3	53.8
3	Eagles	133	2022	17	14	3	0	59	477	28.1	344	20.2	385	45.9	68.8
4	Chiefs	127	2022	17	14	3	0	61	496	29.2	369	21.7	408	48.7	75.0
5	Cowboys	125	2022	17	12	5	0	55	467	27.5	342	20.1	347	45.5	52.6
6	Bengals	96	2022	16	12	4	0	50	418	26.1	322	20.1	357	46.1	25.0
7	Jaguars	54	2022	17	9	8	0	45	404	23.8	350	20.6	352	41.9	51.9
8	Ravens	35	2022	17	10	7	0	34	350	20.6	315	18.5	337	41.7	40.0
9	Lions	26	2022	17	9	8	0	54	453	26.6	427	25.1	376	40.8	54.1
10	Patriots	17	2022	17	8	9	0	39	364	21.4	347	20.4	288	34.9	38.5
11	Chargers	7	2022	17	10	7	0	42	391	23.0	384	22.6	352	43.6	51.7
12	Seahawks	6	2022	17	9	8	0	44	407	23.9	401	23.6	346	37.8	57.1
13	Packers	-1	2022	17	8	9	0	42	370	21.8	371	21.8	334	39.5	38.7
14	Dolphins	-2	2022	17	9	8	0	46	397	23.4	399	23.5	342	36.2	54.2
15	Vikings	-3	2022	17	13	4	0	50	424	24.9	427	25.1	382	41.2	47.4
16	Giants	-6	2022	17	9	7	1	40	365	21.5	371	21.8	352	36.8	47.6
17	Saints	-15	2022	17	7	10	0	37	330	19.4	345	20.3	305	40.2	36.4
18	Browns	-20	2022	17	7	10	0	42	361	21.2	381	22.4	350	38.1	54.8
19	Jets	-20	2022	17	7	10	0	29	296	17.4	316	18.6	294	34.6	39.3
20	Falcons	-21	2022	17	7	10	0	38	365	21.5	386	22.7	330	41.8	50.0
21	Commanders	-22	2022	17	8	8	1	36	321	18.9	343	20.2	339	35.2	48.0
22	Raiders	-23	2022	17	6	11	0	43	395	23.2	418	24.6	343	39.9	54.2
23	Panthers	-27	2022	17	7	10	0	36	347	20.4	374	22.0	281	31.7	57.1
24	Steelers	-38	2022	17	9	8	0	29	308	18.1	346	20.4	345	44.9	73.3
25	Buccaneers	-45	2022	17	8	9	0	32	313	18.4	358	21.1	346	37.4	55.6