| TEAM | DATE | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 12/1/2024 |  SF | +265 | @ |  BUF | -330 | L 10-35 | +6.5 | -18.5 (N) | 45.5 | -0.5 (U) | 1 | 15 | 239 | 372 | 30.0 | 100.0 |
| 2 | | 49ers | 12/7/2020 | SF | -124 | vs | BUF | +105 | L 24-34 | -1.5 | -11.5 (N) | 48 | +10 (O) | 3 | 24 | 402 | 449 | 54.5 | 0.0 |
| 3 | | 49ers | 10/16/2016 | SF | +280 | @ | BUF | -345 | L 16-45 | +7.5 | -21.5 (N) | 44.5 | +16.5 (O) | 1 | 16 | 300 | 492 | 23.1 | 0.0 |
| 4 | | 49ers | 10/7/2012 | SF | -500 | vs | BUF | +400 | W 45-3 | -10 | +32 (Y) | 45.5 | +2.5 (O) | 6 | 29 | 621 | 204 | 63.6 | 100.0 |
| 5 | | 49ers | 11/30/2008 | SF | +245 | @ | BUF | -290 | W 10-3 | +6.5 | +13.5 (Y) | 43 | -30 (U) | 1 | 12 | 195 | 350 | 46.7 | |
| 6 | | 49ers | 12/26/2004 | SF | vs | BUF | L 7-41 | +11.5 | -22.5 (N) | 44 | +4 (O) | 1 | 12 | 189 | 441 | 30.0 | 100.0 | ||
| 7 | | 49ers | 12/2/2001 | SF | vs | BUF | W 35-0 | -8 | +27 (Y) | 42 | -7 (U) | 5 | 26 | 409 | 191 | 66.7 | 0.0 | ||
| 8 | | 49ers | 10/4/1998 | SF | @ | BUF | L 21-26 | -10 | -15 (N) | 44 | +3 (O) | 3 | 23 | 377 | 352 | 46.2 | |||
| 9 | | 49ers | 12/3/1995 | SF | vs | BUF | W 27-17 | -14 | -4 (N) | 46 | -2 (U) | 3 | 18 | 323 | 275 | 31.3 | 50.0 | ||
| 10 | | 49ers | 9/13/1992 | SF | vs | BUF | L 31-34 | -3.5 | -6.5 (N) | 44.5 | +20.5 (O) | 4 | 26 | 598 | 488 | 61.5 | 100.0 | ||
| 11 | | 49ers | 12/17/1989 | SF | vs | BUF | W 21-10 | -5 | +6 (Y) | 43.5 | -12.5 (U) | 3 | 18 | 283 | 301 | ||||
| 12 | | 49ers | 12/11/1983 | SF | @ | BUF | W 23-10 | -1.5 | +11.5 (Y) | 39 | -6 (U) | 2 | 19 | 310 | 303 | ||||
| 13 | | 49ers | 12/21/1980 | SF | vs | BUF | L 13-18 | +6 | +1 (Y) | 42 | -11 (U) | 2 | 19 | 298 | 267 | ||||
| 14 | | 49ers | 9/24/1972 | SF | @ | BUF | L 20-27 | 2 | 10 | 202 | 233 |
Results may be incomplete. StatMuse has complete team, game-level data for spreads going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
22.9
13th
OPP PPG
25.6
29th
RUSH YDS/G
127.2
12th
PASS YDS/G
260.2
4th
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
 Lions | 15 | 2 | 0 | .882 |
 Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
 Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
 Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
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