Shaquille O'Neal averaged 16.7 points, 9.2 rebounds and 1.7 assists in 11 games versus Kobe Bryant in his career.
| NAME | DATE | TM | OPP | MIN | PTS | REB | AST | STL | BLK | FGM | FGA | FG% | 3PM | 3PA | 3P% | FTM | FTA | FT% | TS% | OREB | DREB | TOV | PF | +/- | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | S. O'Neal | 12/25/2004 |  MIA | @ |  LAL | 39 | 24 | 11 | 3 | 0 | 3 | 11 | 19 | 57.9 | 0 | 0 | 2 | 7 | 28.6 | 54.3 | 4 | 7 | 1 | 6 | -3 | |
| 2 | | S. O'Neal | 3/17/2005 | MIA | vs | LAL | 37 | 25 | 12 | 2 | 1 | 4 | 11 | 19 | 57.9 | 0 | 0 | 3 | 9 | 33.3 | 54.4 | 4 | 8 | 2 | 1 | 0 | |
| 3 | | S. O'Neal | 12/25/2005 | MIA | vs | LAL | 34 | 18 | 17 | 3 | 0 | 1 | 8 | 18 | 44.4 | 0 | 0 | 2 | 5 | 40.0 | 44.6 | 6 | 11 | 6 | 4 | -7 | |
| 4 | | S. O'Neal | 1/16/2006 | MIA | @ | LAL | 32 | 18 | 10 | 1 | 0 | 0 | 8 | 14 | 57.1 | 0 | 0 | 2 | 8 | 25.0 | 51.4 | 6 | 4 | 1 | 5 | -10 | |
| 5 |  | S. O'Neal | 2/20/2008 |  PHX | vs | LAL | 29 | 15 | 9 | 3 | 0 | 2 | 6 | 9 | 66.7 | 0 | 0 | 3 | 8 | 37.5 | 59.9 | 4 | 5 | 3 | 5 | -1 | |
| 6 | | S. O'Neal | 11/20/2008 | PHX | vs | LAL | 27 | 15 | 9 | 1 | 0 | 0 | 6 | 12 | 50.0 | 0 | 0 | 3 | 6 | 50.0 | 51.2 | 6 | 3 | 4 | 3 | -7 | |
| 7 | | S. O'Neal | 2/26/2009 | PHX | @ | LAL | 21 | 12 | 7 | 0 | 0 | 2 | 3 | 7 | 42.9 | 0 | 0 | 6 | 7 | 85.7 | 59.5 | 2 | 5 | 2 | 2 | -13 | |
| 8 | | S. O'Neal | 3/1/2009 | PHX | vs | LAL | 35 | 33 | 7 | 3 | 0 | 0 | 13 | 18 | 72.2 | 0 | 0 | 7 | 12 | 58.3 | 70.9 | 2 | 5 | 6 | 6 | +16 | |
| 9 |  | S. O'Neal | 12/25/2009 |  CLE | @ | LAL | 22 | 11 | 7 | 0 | 0 | 0 | 5 | 8 | 62.5 | 0 | 0 | 1 | 4 | 25.0 | 56.4 | 2 | 5 | 0 | 5 | +9 | |
| 10 | | S. O'Neal | 1/21/2010 | CLE | vs | LAL | 28 | 13 | 6 | 3 | 1 | 1 | 5 | 9 | 55.6 | 0 | 0 | 3 | 4 | 75.0 | 60.4 | 1 | 5 | 2 | 3 | +3 | |
| 11 |  | S. O'Neal | 1/30/2011 |  BOS | @ | LAL | 13 | 0 | 6 | 0 | 0 | 2 | 0 | 2 | 0.0 | 0 | 0 | 0 | 0 | 0.0 | 2 | 4 | 2 | 5 | -4 | ||
| Average | 28.8 | 16.7 | 9.2 | 1.7 | 0.2 | 1.4 | 6.9 | 12.3 | 56.3 | 0.0 | 0.0 | 2.9 | 6.4 | 45.7 | 55.5 | 3.5 | 5.6 | 2.6 | 4.1 | -1.5 | |||||||
| Total | 317 | 184 | 101 | 19 | 2 | 15 | 76 | 135 | 56.3 | 0 | 0 | 32 | 70 | 45.7 | 55.5 | 39 | 62 | 29 | 45 | -17 |
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