Luc Mbah a Moute has the highest plus/minus in a game, at +57 against the Nuggets on November 22, 2017.

Interpreted as:

highest plus minus by a player in a regular-season game ever

	NAME	+/-	DATE	TM		OPP	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Luc Mbah a Moute L. Mbah a Moute	+57	11/22/2017	HOU	vs	DEN	26	13	4	1	4	0	5	5	100.0	3	3	100.0	0	0		130.0	0	4	2	3
2	Gary Trent Jr. G. Trent Jr.	+54	4/2/2021	TOR	vs	GSW	30	24	5	1	1	2	8	14	57.1	6	9	66.7	2	2	100.0	80.6	0	5	0	1
3	Santi Aldama S. Aldama	+52	12/2/2021	MEM	vs	OKC	28	18	10	3	1	1	8	16	50.0	0	3	0.0	2	3	66.7	52.0	5	5	0	1
4	Joe Smith J. Smith	+52	11/8/2001	MIN	vs	CHI	27	17	8	3	1	0	7	10	70.0	0	0		3	4	75.0	72.3	3	5	1	2
5	Jeremy Lamb J. Lamb	+51	3/22/2018	CHA	vs	MEM	26	12	9	6	1	0	4	7	57.1	2	4	50.0	2	2	100.0	76.1	0	9	3	2
6	James Harden J. Harden	+50	11/30/2019	HOU	vs	ATL	31	60	3	8	3	1	16	24	66.7	8	14	57.1	20	23	87.0	87.9	0	3	5	3
7	Daniel Theis D. Theis	+50	12/8/2018	BOS	@	CHI	32	22	10	5	1	4	8	15	53.3	2	4	50.0	4	7	57.1	60.8	4	6	0	3
8	Jared Jeffries J. Jeffries	+50	10/31/2002	WAS	vs	BOS	29	12	5	1	0	0	5	7	71.4	2	2	100.0	0	1	0.0	80.6	1	4	1	1
9	Wally Szczerbiak W. Szczerbiak	+50	11/8/2001	MIN	vs	CHI	22	13	2	3	0	0	6	8	75.0	1	1	100.0	0	0		81.3	0	2	1	1
10	Domantas Sabonis D. Sabonis	+49	5/1/2021	IND	@	OKC	30	26	19	14	1	0	10	13	76.9	2	3	66.7	4	6	66.7	83.1	0	19	5	2
11	Oshae Brissett O. Brissett	+49	5/1/2021	IND	@	OKC	40	16	13	3	0	4	6	11	54.5	3	6	50.0	1	3	33.3	64.9	1	12	1	3
12	Pascal Siakam P. Siakam	+49	4/2/2021	TOR	vs	GSW	31	36	7	5	2	0	14	24	58.3	4	9	44.4	4	4	100.0	69.9	0	7	0	2
13	Amar'e Stoudemire A. Stoudemire	+49	2/2/2009	PHX	vs	SAC	28	25	8	0	1	0	6	12	50.0	0	0		13	13	100.0	70.5	3	5	2	3
14	Tyronn Lue T. Lue	+49	10/31/2002	WAS	vs	BOS	35	10	5	5	0	0	4	8	50.0	2	5	40.0	0	0		62.5	0	5	1	2
15	Steve Smith S. Smith	+49	4/19/1997	ATL	vs	PHI	28	21	4	7	1	0	9	12	75.0	3	3	100.0	0	0		87.5	0	4	0	0
16	Shelvin Mack S. Mack	+48	3/28/2016	UTA	vs	LAL	29	17	3	5	0	0	8	11	72.7	1	3	33.3	0	0		77.3	0	3	2	0
17	Ronnie Brewer R. Brewer	+48	1/1/2012	CHI	vs	MEM	35	17	7	5	2	0	6	10	60.0	1	1	100.0	4	4	100.0	72.3	1	6	3	2
18	Chauncey Billups C. Billups	+48	12/2/2008	DEN	vs	TOR	32	24	1	14	1	0	8	12	66.7	5	6	83.3	3	3	100.0	90.1	0	1	1	0
19	Terrell Brandon T. Brandon	+48	11/8/2001	MIN	vs	CHI	23	14	3	12	4	0	5	9	55.6	0	0		4	4	100.0	65.1	0	3	1	0
20	Jaren Jackson Jr. J. Jackson Jr.	+47	3/8/2022	MEM	vs	NOP	24	22	3	0	1	3	7	13	53.8	2	6	33.3	6	6	100.0	70.3	0	3	0	4
21	Caris LeVert C. LeVert	+47	5/1/2021	IND	@	OKC	27	25	1	6	1	2	9	15	60.0	4	6	66.7	3	3	100.0	76.6	0	1	1	3
22	Kemba Walker K. Walker	+47	3/22/2018	CHA	vs	MEM	28	46	3	4	1	0	13	18	72.2	10	14	71.4	10	10	100.0	102.7	0	3	2	1
23	Marvin Williams M. Williams	+47	3/22/2018	CHA	vs	MEM	28	15	6	0	2	1	5	8	62.5	2	5	40.0	3	4	75.0	76.8	1	5	0	0
24	Chris Paul C. Paul	+47	2/3/2018	HOU	@	CLE	27	22	8	11	1	0	8	14	57.1	6	9	66.7	0	0		78.6	1	7	0	4
25	Darren Collison D. Collison	+47	2/19/2012	IND	vs	CHA	29	11	2	6	1	0	2	6	33.3	1	1	100.0	6	6	100.0	63.7	0	2	1	0