The Oklahoma City Thunder have the lowest point differential by a team in a game, with a -73 point differential against the Grizzlies on December 2, 2021.

Interpreted as:

biggest losses in a regular-season game in NBA history

	TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Thunder	-73	12/2/2021	OKC	@	MEM	L 79-152	240	79	26	14	2	5	25	76	32.9	11	38	28.9	18	22	81.8	46.1	8	18	19	14
2	Heat	-68	12/17/1991	MIA	@	CLE	L 80-148	240	80	41	18	7	5	33	93	35.5	6	14	42.9	8	11	72.7	40.9	17	24	23	24
3	Trail Blazers	-65	2/27/1998	POR	@	IND	L 59-124	240	59	28	16	10	5	24	72	33.3	3	17	17.6	8	19	42.1	36.7	10	18	22	25
4	Warriors	-63	3/19/1972	GSW	@	LAL	L 99-162	240	99	54	15			40	117	34.2				19	29	65.5	38.1				23
5	Trail Blazers	-62	1/11/2024	POR	@	OKC	L 77-139	240	77	42	16	8	8	28	101	27.7	11	49	22.4	10	16	62.5	35.6	13	29	9	19
6	Kings	-62	11/2/1991	SAC	@	GSW	L 91-153	240	91	29	28	10	5	39	98	39.8	5	10	50.0	8	12	66.7	44.1	11	18	28	25
7	Knicks	-62	12/25/1960	NYK	@	SYR	L 100-162	240	100					34						32	42	76.2					25
8	Grizzlies	-61	3/22/2018	MEM	@	CHA	L 79-140	240	79	38	13	4	7	30	78	38.5	4	18	22.2	15	21	71.4	45.3	9	29	19	24
9	Trail Blazers	-60	3/29/2024	POR	@	MIA	L 82-142	240	82	43	20	4	2	35	87	40.2	5	30	16.7	7	11	63.6	44.6	10	33	23	19
10	Nets	-59	1/15/2025	BKN	@	LAC	L 67-126	240	67	39	15	9	2	25	83	30.1	5	28	17.9	12	22	54.5	36.1	15	24	20	16
11	Pistons	-59	12/26/1978	DET	@	MIL	L 84-143	240	84	32	28	10	10	40	96	41.7				4	12	33.3	41.5			32	20
12	Pacers	-59	3/19/1977	IND	@	GSW	L 91-150	240	91	45	27	11	9	39	99	39.4				13	21	61.9	42.0	18	27	28	27
13	Mavericks	-58	12/29/1992	DAL	@	SAC	L 81-139	240	81	37	14	8	8	32	85	37.6	0	4	0.0	17	23	73.9	42.6	9	28	28	33
14	Kings	-58	12/15/1985	SAC	@	MIL	L 82-140	240	82	31	19	11	1	31	83	37.3	0	1	0.0	20	24	83.3	43.8	16	15	29	30
15	Thunder	-57	5/1/2021	OKC	vs	IND	L 95-152	240	95	48	23	8	4	38	111	34.2	8	38	21.1	11	23	47.8	39.2	21	27	14	15
16	Trail Blazers	-56	4/9/2023	POR	vs	GSW	L 101-157	240	101	30	25	5	3	38	95	40.0	9	35	25.7	16	24	66.7	47.8	6	24	14	9
17	Bulls	-56	12/8/2018	CHI	vs	BOS	L 77-133	240	77	37	16	3	2	31	81	38.3	6	24	25.0	9	14	64.3	44.2	8	29	15	17
18	76ers	-56	3/6/1993	PHI	@	SEA	L 93-149	240	93	42	13	7	2	36	93	38.7	5	15	33.3	16	21	76.2	45.5	17	25	22	17
19	76ers	-56	1/2/1993	PHI	@	SAC	L 98-154	240	98	37	23	8	7	32	82	39.0	4	9	44.4	30	39	76.9	49.4	8	29	29	23
20	Rockets	-56	12/6/1986	HOU	vs	SEA	L 80-136	240	80	37	17	9	2	31	93	33.3	0	5	0.0	18	25	72.0	38.5	20	17	19	25
21	Jazz	-56	3/14/1979	NOJ	@	MIL	L 102-158	240	102	36	27	6	2	41	99	41.4				20	27	74.1	46.0				15
22	Trail Blazers	-56	2/20/1976	POR	@	CHI	L 74-130	240	74	45	14	3	2	33	81	40.7				8	16	50.0	42.0	16	29		29
23	Pistons	-56	11/12/1966	DET	@	LAL	L 88-144	240	88	41	23			35	107	32.7				18	27	66.7	37.0				32
24	Cavaliers	-55	1/11/2011	CLE	@	LAL	L 57-112	240	57	42	12	9	4	23	77	29.9	1	14	7.1	10	16	62.5	33.9	14	28	19	17
25	Kings	-55	4/17/1989	SAC	@	PHX	L 85-140	240	85	39	19	7	2	33	86	38.4	2	11	18.2	17	20	85.0	44.8	17	22	23	31