Delcath Systems (DCTH) had the lowest return between 2017 and 2021 by a US stock, returning -100%.

ASSET	YEARS	% RETURN
Delcath Systems (DCTH)	2017-2021	-100%
Bayfirst Financial (BAFN)	2017-2021	-100%
MetroCity Bankshares (MCBS)	2017-2021	-100%
GeoVax Labs (GOVX)	2017-2021	-99.99%
Creative Medical Technology (CELZ)	2017-2021	-99.99%
TOP Ships (TOPS)	2017-2021	-99.98%
Performance Shipping (PSHG)	2017-2021	-99.98%
Synergy CHC Corp Common Stock (SNYR)	2017-2021	-99.98%
Aytu BioScience (AYTU)	2017-2021	-99.97%
Avinger (AVGR)	2017-2021	-99.97%
BioRestorative Therapies (BRTX)	2017-2021	-99.97%
Globus Maritime (GLBS)	2017-2021	-99.95%
Plus Therapeutics (PSTV)	2017-2021	-99.86%
Titan Pharmaceuticals (TTNP)	2017-2021	-99.86%
Enveric Biosciences (ENVB)	2017-2021	-99.86%
Qualigen Therapeutics (QLGN)	2017-2021	-99.84%
InspireMD (NSPR)	2017-2021	-99.84%
Hepion Pharmaceuticals (HEPA)	2017-2021	-99.83%
Sellas Life Sciences (SLS)	2017-2021	-99.81%
Red Cat (RCAT)	2017-2021	-99.79%
Tonix Pharmaceuticals (TNXP)	2017-2021	-99.76%
Phio Pharmaceuticals (PHIO)	2017-2021	-99.76%
Palisade Bio (PALI)	2017-2021	-99.72%
Catheter Precision (VTAK)	2017-2021	-99.71%
Seanergy Maritime (SHIP)	2017-2021	-99.67%