Know Labs (KNW) had the highest return between 2000 and 2010 by a US stock, returning 4,885,152.2%.

ASSET	YEARS	% RETURN
Know Labs (KNW)	2000-2010	4,885,152.16%
Perspective Therapeutics (CATX)	2000-2010	376,566.67%
Aris Mining (ARMN)	2000-2010	326,443.75%
Gulf Resources (GURE)	2000-2010	53,350%
Houston American Energy (HUSA)	2000-2010	37,506.02%
Pioneer Power Solutions (PPSI)	2000-2010	29,429.23%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2000-2010	21,400%
Frontline (FRO)	2000-2010	18,508.35%
Companhia Siderurgica Nacional ADR (SID)	2000-2010	13,527.53%
Monster Beverage (MNST)	2000-2010	9,668.39%
Deckers Outdoor (DECK)	2000-2010	9,015.23%
MEDIFAST (MED)	2000-2010	8,301.96%
BRF SA ADR (BRFS)	2000-2010	7,599.85%
Ainos (AIMD)	2000-2010	7,207.69%
Clean Harbors (CLH)	2000-2010	6,798.59%
BP Prudhoe Bay Royalty Trust (BPT)	2000-2010	5,944.93%
BTCS (BTCS)	2000-2010	5,920%
Banco Bradesco SA ADR (BBD)	2000-2010	5,153.95%
Denison Mines (DNN)	2000-2010	4,588.94%
McEwen Mining (MUX)	2000-2010	4,262.78%
China Yuchai International (CYD)	2000-2010	4,044.78%
Dmc Global (BOOM)	2000-2010	3,636.37%
Mesabi Trust (MSB)	2000-2010	3,452.85%
Southern Copper (SCCO)	2000-2010	3,418.01%
Altria (MO)	2000-2010	3,340.01%