Know Labs (KNW) had the highest return between 1999 and 2008 by a US stock, returning 534,224.4%.

ASSET	YEARS	% RETURN
Know Labs (KNW)	1999-2008	534,224.43%
Perspective Therapeutics (CATX)	1999-2008	66,566.67%
Frontline (FRO)	1999-2008	19,308.26%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	1999-2008	9,947.37%
Companhia Siderurgica Nacional ADR (SID)	1999-2008	7,685.42%
TherapeuticsMD (TXMD)	1999-2008	7,439.95%
Houston American Energy (HUSA)	1999-2008	6,731.48%
Ainos (AIMD)	1999-2008	6,157.49%
BP Prudhoe Bay Royalty Trust (BPT)	1999-2008	5,658.1%
Broadwind Energy (BWEN)	1999-2008	5,300.22%
Monster Beverage (MNST)	1999-2008	4,898.57%
Clean Harbors (CLH)	1999-2008	3,804%
Deckers Outdoor (DECK)	1999-2008	3,657.15%
Oramed Pharmaceuticals (ORMP)	1999-2008	3,134.28%
Gerdau SA ADR (GGB)	1999-2008	2,970.05%
FTI Consulting (FCN)	1999-2008	2,934.91%
BRF SA ADR (BRFS)	1999-2008	2,860.41%
BlackBerry (BB)	1999-2008	2,008.6%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2008	1,922.71%
American Vanguard (AVD)	1999-2008	1,914.83%
Gilead Sciences (GILD)	1999-2008	1,895.78%
Banco Bradesco SA ADR (BBD)	1999-2008	1,817.93%
SSR Mining (SSRM)	1999-2008	1,789.15%
Amedisys (AMED)	1999-2008	1,776.45%
Laboratory Corporation of America (LH)	1999-2008	1,773.88%