Crown Electrokinetics (CRKN) had the highest return in 2021 by a US stock, returning 4,766,925.1%.

ASSET	YEAR	% RETURN
Crown Electrokinetics (CRKN)	2021	4,766,925.09%
A2Z Smart Technologies (AZ)	2021	1,592,547.06%
XORTX Therapeutics (XRTX)	2021	1,229,900%
authID (AUID)	2021	634,024.29%
Zhihu Inc ADR (ZH)	2021	455,242.47%
Connexa Sports Technologies (YYAI)	2021	152,788.89%
KWESST Micro Systems Inc Common Stock (KWE)	2021	68,499.72%
Ainos (AIMD)	2021	31,400%
Sobr Safe (SOBR)	2021	31,173.13%
Applied Blockchain (APLD)	2021	11,073.33%
SDCL EDGE Acquisition (SEDA.UN)	2021	6,755.1%
Draganfly (DPRO)	2021	5,818.66%
Kaival Brands Innovations (KAVL)	2021	3,538.37%
Destination XL (DXLG)	2021	2,067.94%
High Tide (HITI)	2021	2,022.88%
Zivo Bioscience (ZIVO)	2021	1,788.16%
Dogwood Therapeutics (DWTX)	2021	1,602.73%
Lightwave Logic (LWLG)	2021	1,500%
Electra Battery Materials (ELBM)	2021	1,254.13%
AMC Entertainment (AMC)	2021	1,136.36%
Arqit Quantum Inc Warrants (ARQQW)	2021	1,060%
LakeShore Biopharma (LSB)	2021	923.16%
Aehr Test Systems (AEHR)	2021	867.2%
Empire Petroleum (EP)	2021	814.42%
Greenwave Technology Solutions Inc Common Stock (GWAV)	2021	683.33%