Domino's Pizza Inc Common Stock (DPZ) had the highest return between 2010 and 2016 by a US stock in the S&P 500 (GSPC), returning 2,017%.

ASSET	YEARS	% RETURN
Domino's Pizza Inc Common Stock (DPZ)	2010-2016	2,016.97%
Netflix (NFLX)	2010-2016	1,460.88%
Regeneron Pharmaceuticals (REGN)	2010-2016	1,414.4%
Ulta Beauty (ULTA)	2010-2016	1,240.58%
Caesars Entertainment (CZR)	2010-2016	1,203.85%
MarketAxess (MKTX)	2010-2016	1,079.68%
Tesla (TSLA)	2010-2016	1,024.65%
Incyte (INCY)	2010-2016	987.53%
United Rentals (URI)	2010-2016	964.32%
Broadcom (AVGO)	2010-2016	964.27%
Texas Pacific Land Trust (TPL)	2010-2016	916.36%
Constellation Brands Inc Class A (STZ)	2010-2016	873.49%
Charter Communications (CHTR)	2010-2016	722.63%
Transdigm (TDG)	2010-2016	722.51%
NXP Semiconductors (NXPI)	2010-2016	653.93%
DexCom (DXCM)	2010-2016	627.16%
Smith AO (AOS)	2010-2016	615.42%
Tyler Technologies (TYL)	2010-2016	612.07%
O’Reilly Automotive (ORLY)	2010-2016	609.51%
Monster Beverage (MNST)	2010-2016	588.17%
Booking (BKNG)	2010-2016	559.44%
Ross Stores (ROST)	2010-2016	559.34%
Old Dominion Freight Line (ODFL)	2010-2016	528.75%
NVIDIA (NVDA)	2010-2016	519.6%
Pool (POOL)	2010-2016	505.95%