Qilian International (QLI) had the highest return in 2021 by a US stock, returning 4,285,900%.

ASSET	YEAR	% RETURN
Qilian International (QLI)	2021	4,285,900%
Zhihu Inc ADR (ZH)	2021	455,242.47%
Ainos (AIMD)	2021	31,400%
Applied Blockchain (APLD)	2021	11,073.33%
SDCL EDGE Acquisition (SEDA.UN)	2021	6,755.1%
Digihost Technology (DGHI)	2021	4,330.62%
Destination XL (DXLG)	2021	2,067.94%
High Tide (HITI)	2021	2,022.88%
Lightwave Logic (LWLG)	2021	1,500%
Electra Battery Materials (ELBM)	2021	1,254.13%
AMC Entertainment (AMC)	2021	1,136.36%
Arqit Quantum Inc Warrants (ARQQW)	2021	1,060%
Aehr Test Systems (AEHR)	2021	867.2%
Empire Petroleum (EP)	2021	778.79%
Greenwave Technology Solutions Inc Common Stock (GWAV)	2021	683.33%
GameStop (GME)	2021	681%
Everest Consolidator Acquisition (MNTN.UN)	2021	615.3%
Cerberus Cyber Sentinel (CISO)	2021	584.21%
BriaCell Therapeutics (BCTXW)	2021	560.56%
Cassava Sciences (SAVA)	2021	538.89%
Obsidian Energy (OBE)	2021	514.93%
Sangoma Technologies (SANG)	2021	513.09%
Vertex Energy (VTNR)	2021	499.21%
Mega Matrix (MPU)	2021	479.19%
Birks (BGI)	2021	464.02%