Regeneron Pharmaceuticals (REGN) had the highest return between 2010 and 2015 by a US stock in the S&P 500 (GSPC), returning 2,139.6%.

ASSET	YEARS	% RETURN
Regeneron Pharmaceuticals (REGN)	2010-2015	2,139.56%
Domino's Pizza Inc Common Stock (DPZ)	2010-2015	1,363.15%
Netflix (NFLX)	2010-2015	1,342.12%
Tesla (TSLA)	2010-2015	1,163.18%
Incyte (INCY)	2010-2015	1,076.25%
DexCom (DXCM)	2010-2015	897.56%
Ulta Beauty (ULTA)	2010-2015	872.8%
Constellation Brands Inc Class A (STZ)	2010-2015	795.84%
MarketAxess (MKTX)	2010-2015	789%
Tyler Technologies (TYL)	2010-2015	769.43%
Broadcom (AVGO)	2010-2015	760.74%
Caesars Entertainment (CZR)	2010-2015	746.15%
Monster Beverage (MNST)	2010-2015	670.63%
United Rentals (URI)	2010-2015	631.25%
Transdigm (TDG)	2010-2015	590.44%
Tractor Supply (TSCO)	2010-2015	575.27%
NXP Semiconductors (NXPI)	2010-2015	548.08%
O’Reilly Automotive (ORLY)	2010-2015	545.82%
Centene (CNC)	2010-2015	515.05%
Booking (BKNG)	2010-2015	473.48%
Smith AO (AOS)	2010-2015	472%
EPAM Systems (EPAM)	2010-2015	471.78%
Corpay (CPAY)	2010-2015	471.72%
Biogen (BIIB)	2010-2015	467.63%
LyondellBasell Industries (LYB)	2010-2015	452.94%