Perspective Therapeutics (CATX) had the highest return in the 2000s by a US stock, returning 296,566.7%.

ASSET	DECADE	% RETURN
Perspective Therapeutics (CATX)	2000s	296,566.67%
United Community Banks (UCB)	2000s	102,093.5%
Gulf Resources (GURE)	2000s	58,200%
Know Labs (KNW)	2000s	26,617.56%
TherapeuticsMD (TXMD)	2000s	19,503.88%
Frontline (FRO)	2000s	18,585.8%
Ainos (AIMD)	2000s	15,428.85%
Companhia Siderurgica Nacional ADR (SID)	2000s	12,543.98%
Houston American Energy (HUSA)	2000s	12,534.48%
Broadwind Energy (BWEN)	2000s	9,608.39%
MEDIFAST (MED)	2000s	8,796.54%
Monster Beverage (MNST)	2000s	7,074.89%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2000s	6,230.77%
BRF SA ADR (BRFS)	2000s	5,806.86%
Clean Harbors (CLH)	2000s	4,790.88%
Amedisys (AMED)	2000s	4,612.96%
Banco Bradesco SA ADR (BBD)	2000s	4,320.85%
Deckers Outdoor (DECK)	2000s	3,775.93%
Oramed Pharmaceuticals (ORMP)	2000s	3,631.86%
BP Prudhoe Bay Royalty Trust (BPT)	2000s	3,464.18%
Dmc Global (BOOM)	2000s	3,188.36%
Gerdau SA ADR (GGB)	2000s	2,419.97%
Vale SA ADR (VALE)	2000s	2,310.13%
Range Resources (RRC)	2000s	2,203.49%
Southern Copper (SCCO)	2000s	2,157.79%