Genmab A-S (GMAB) had the highest return between 2013 and 2015 by a large-cap US stock, returning 857.3%.

ASSET	YEARS	% RETURN
Genmab A-S (GMAB)	2013-2015	857.29%
Netflix (NFLX)	2013-2015	740.94%
Neurocrine Biosciences (NBIX)	2013-2015	636.59%
Tesla (TSLA)	2013-2015	585.75%
Incyte (INCY)	2013-2015	548.62%
DexCom (DXCM)	2013-2015	489.63%
Intracellular Th (ITCI)	2013-2015	437.9%
Alnylam Pharmaceuticals (ALNY)	2013-2015	396.78%
Skechers (SKX)	2013-2015	375.25%
Broadcom (AVGO)	2013-2015	370.2%
Electronic Arts (EA)	2013-2015	365.27%
NetEase (NTES)	2013-2015	345.99%
Delta Air Lines (DAL)	2013-2015	329.69%
Manhattan Associates (MANH)	2013-2015	326.7%
EPAM Systems (EPAM)	2013-2015	324.51%
Southwest Airlines (LUV)	2013-2015	321.59%
Constellation Brands Inc Class A (STZ)	2013-2015	299.2%
Grupo Financiero Galicia SA ADR (GGAL)	2013-2015	296.71%
Trip Group Ltd ADR (TCOM)	2013-2015	294.3%
Facebook (META)	2013-2015	281.42%
Skyworks Solutions (SWKS)	2013-2015	271.09%
Pilgrims Pride (PPC)	2013-2015	256.04%
Tyler Technologies (TYL)	2013-2015	252.87%
Diamondback Energy (FANG)	2013-2015	243.78%
Illumina (ILMN)	2013-2015	242.16%

Large-cap stocks are treated as having a market cap of $10B+.